325489-02-9

Upstream product

• 325489-01-8 3-methoxy-5-methoxymethyl-cyclohex-2-enone 
• 227201-35-6 1,5-dimethoxy-3-methoxymethyl-cyclohexa-1,4-diene 
• 90612-16-1 (3,5-dimethoxycyclohexa-2,5-dien-1-yl)methanol 

Downstream Products

• 325489-06-3 toluene-4-sulfonic acid 5-oxo-5,6,7,8-tetrahydro-quinolin-7-ylmethyl ester 

Relevant academic research and scientific papers

Efficient synthesis of quinazolinones as intermediates of CNS agents via inverse-electron demand Diels-Alder reaction

Enaminones undergo inverse electron demand Diels-Alder reaction with 1,3,5-triazine, allowing access to functionalised quinazolinones as intermediates in the synthesis of CNS agents. This reaction is highly dependent of the solvent: 1,3,5-triazine undergo

A simple, efficient method for regioselective synthesis of 7-aminomethyl-7,8-dihydro-6H-quinolin-5-ones, new potential CNS agents

We have developed an efficient and convenient strategy for the regioselective synthesis of new conformationally restricted butyrophenones of the quinoline series. The 7-aminomethyl-7,8-dihydro-6H-quinolin-5-ones 9 were obtained from protected alcohol 5 via the tosylate, and also in a one-pot reaction via bromo derivative 6, with moderate-to-good overall yields in both cases. (C) 2000 Elsevier Science Ltd.