325489-06-3

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 325489-05-2 7-hydroxymethyl-7,8-dihydro-6H-quinolin-5-one 
• 325489-03-0 7-methoxymethyl-7,8-dihydro-6H-quinolin-5-one 
• 325489-01-8 3-methoxy-5-methoxymethyl-cyclohex-2-enone 
• 325489-02-9 3-amino-5-methoxymethyl-2-cyclohexen-1-one 
• 227201-35-6 1,5-dimethoxy-3-methoxymethyl-cyclohexa-1,4-diene 
• 90612-16-1 (3,5-dimethoxycyclohexa-2,5-dien-1-yl)methanol 

Relevant academic research and scientific papers

A simple, efficient method for regioselective synthesis of 7-aminomethyl-7,8-dihydro-6H-quinolin-5-ones, new potential CNS agents

We have developed an efficient and convenient strategy for the regioselective synthesis of new conformationally restricted butyrophenones of the quinoline series. The 7-aminomethyl-7,8-dihydro-6H-quinolin-5-ones 9 were obtained from protected alcohol 5 via the tosylate, and also in a one-pot reaction via bromo derivative 6, with moderate-to-good overall yields in both cases. (C) 2000 Elsevier Science Ltd.