32550-63-3Relevant academic research and scientific papers
Synthesis, antibacterial and QSAR evaluation of 5-oxo and 5-thio derivatives of 1,4-disubstituted tetrazoles
Morjan, Rami Y.,Al-Attar, Nisreen H.,Abu-Teim, Omar S.,Ulrich, Maschke,Awadallah, Adel M.,Mkadmh, Ahmed M.,Elmanama, Abdelrauof A.,Raftery, James,Abu-Awwad, Fakhr M.,Yaseen, Zyad J.,Elqidrea, Ammar F.,Gardiner, John M.
, p. 4024 - 4028 (2015/08/24)
Abstract A series of 1,4-disubstituted tetrazol-5-ones 3a, 5, 7, 12, 13 and 1,4-disubstituted tetrazol-5-thiones 3b, 9, 10 was synthesized and fully characterized by IR, MS, 1H NMR and 13C NMR. The series was evaluated for in vitro antibacterial activity against four Gram negative (Escherichia coli, Proteus mirabilis, Klebsiella pneumonia, and Pseudomonas aeruginosa) and three Gram positive (Staphylococcus aureus, Enterococcus faecalis, and Bacillus subtilis) bacteria. The zone of inhibition was measured using the well-diffusion assay, and in vitro minimum inhibitory concentration (MIC) was determined by microbroth dilution assay. MIC values indicate that compounds exhibited a varied range (0.2-37 μg/mL) of antibacterial activity against the tested bacterial strains. Statistically significant QSAR models were developed by the simple linear regression analysis for the correlation of MIC with computed descriptors. The concluded cross validated regression factors are 0.953 and 0.986 for E. coli, and S. aureus, respectively.
New 1H-Tetrazol-5-thiol Derivatives as Pesticides, II. Cyanodithioimidocarbonic acid esters
Foeldenyi, R.
, p. 1035 - 1044 (2007/10/03)
Depending on the reaction conditions, tetrazoles and tetrazolines were synthesized from 1H-tetrazol-5-thiol derivatives.The heteroring was substituted by cyanodithioimidocarbonate to give either -S-CH2-S or -S-CH2-N=derivatives.Many of them show fungicide
A New Deprotection Method for Levulinyl Protecting Groups under Neutral Conditions
Ono, Mitsunori,Itoh, Isamu
, p. 585 - 588 (2007/10/02)
Sulfit ion-induced cleavage of the levulinyl group under neutral conditions provides a convenient and mild deprotection method especially for alkali labile and/or oxygen sensitive compounds.
