32591-36-9Relevant academic research and scientific papers
Development of a scalable synthesis of a pyridinyl-3-azabicyclononene, a novel nicotinic partial agonist
Breining, Scott R.,Genus, John F,Mitchener, J. Pike,Cuthbertson, Timothy J,Heemstra, Ronald,Melvin, Matt S,Dull, Gary M,Yohannes, Daniel
, p. 413 - 421 (2013)
The process research and development of two syntheses of a novel nicotinic partial agonist, TC-8817 ((+)-5), are described. The original Medicinal Chemistry route had multiple flaws, making it unsuitable for further development. A second approach was expl
PHARMACEUTICAL COMPOSITIONS AND METHODS FOR RELIEVING PAIN AND TREATING CENTRAL NERVOUS SYSTEM DISORDERS
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Page/Page column 93, (2008/06/13)
Patients susceptible to or suffering from disorders, such as central nervous system disorders, which are characterized by an alteration in normal neurotransmitter release, such as dopamine release (e.g., Parkinsonism, Parkinson's Disease, Tourette's Syndrome, attention deficient disorder, or schizophrenia), are treated by administering a compound of Formulas (1 or 2), as described herein. The compounds of Formulas (1 and 2) are also useful for treating pain, and treating drug addiction, nicotine addiction, and/or obesity. The compounds can exist as individual stereoisomers, racemic mixtures, diastereomers and the like.
