326-63-6

Basic information

• Product Name: 2-(2-fluorophenyl)acetamide
• Synonyms: 2-(2-fluorophenyl)acetamide
• CAS NO: 326-63-6
• Molecular Formula: C₈H₈FNO
• Molecular Weight: 153.16
• Mol File: 326-63-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: 157.2-159.2 °C(Solv: benzene (71-43-2))
• Boiling Point: 312.1±25.0 °C(Predicted)
• Appearance: /
• Density: 1.203±0.06 g/cm3(Predicted)
• PKA: 15.94±0.40(Predicted)
• CAS DataBase Reference: 2-(2-fluorophenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-fluorophenyl)acetamide(326-63-6)
• EPA Substance Registry System: 2-(2-fluorophenyl)acetamide(326-63-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 326-63-6(Hazardous Substances Data)

Usage

Chemical structure

2-(2-fluorophenyl)acetamide is an acetamide derivative with a fluorophenyl group attached to the amino group of the acetamide.

Usage

It is often used in pharmaceutical research and drug development.

Potential applications

It has potential applications in the treatment of various medical conditions, including neurological disorders and pain management.

Value in organic synthesis

It is a valuable intermediate in organic synthesis.

Versatility

It is a versatile compound for use in the production of other pharmaceuticals and fine chemicals.

Specific properties and potential biological activities

The presence of the fluorophenyl group imparts specific properties and potential biological activities that make it of interest to researchers in the pharmaceutical and chemical industries.

Upstream product

• 451-81-0 2-(2-fluorophenyl)acetyl chloride 
• 451-82-1 (2-fluorophenyl)acetic acid 
• 326-62-5 2-fluorophenyl acetonitrile 

Downstream Products

• 621-79-4 cinnamamide 
• 584-74-7 o-fluorophenylacetic acid ethyl ester 
• 77418-74-7 3-(2-Fluoro-phenyl)-4-phenyl-piperidine-2,6-dione 
• 18254-00-7 4-methyl-cinnamic acid amide 
• 77418-84-9 3-(2-Fluoro-phenyl)-4-p-tolyl-piperidine-2,6-dione 
• 18166-64-8 4-chlorocinnamide 
• 77418-79-2 4-(4-Chloro-phenyl)-3-(2-fluoro-phenyl)-piperidine-2,6-dione 

Relevant articles and documents

Identification, synthesis and pharmacological evaluation of novel anti-EV71 agents via cyclophilin A inhibition

In this work, the relationship between cyclophilin A (CypA) and EV71 prompted us to screen a series of small molecular CypA inhibitors which were previously reported by our group. Among them, compounds 1 and 2 were discovered as non-immunosuppressive anti-EV71 agents with an EC50 values of 1.07 ± 0.17 μM and 3.36 ± 0.45 μM in virus assay, respectively, which were desirably for the further study. The subsequent chemical modifications derived a novel class of molecules, among which compound 11 demonstrated the most potent anti-EV71 activity in virus assay (EC50 = 0.37 ± 0.17 μM), and low cytotoxicity (CC50 > 25 μM). The following CypA enzyme inhibition studies indicated that there was not only the enzyme inhibition activity, undoubtedly important, functioning in the antiviral process, but also some unknown mechanisms worked in combination, and the further study is underway in our laboratory. Nevertheless, to the best of our knowledge, compound 11 was probably the most potent small molecular anti-EV71 agent via CypA inhibitory mechanism to date. Consequently, our study provided a new potential small molecule for curing EV71 infection.