584-74-7

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 2-fluorophenylacetate is used as an intermediate compound for the synthesis of various pharmaceuticals. Its unique structure allows for the creation of new drug molecules with potential therapeutic applications.
Used in Organic Synthesis:
Ethyl 2-fluorophenylacetate is used as a building block in the synthesis of other organic compounds. Its versatility in chemical reactions makes it a valuable component in the development of new molecules with diverse applications in various industries.
Used in Research and Development:
Ethyl 2-fluorophenylacetate is used as a research compound for studying its chemical properties and potential applications in various fields. Its unique structure and reactivity make it an interesting subject for scientific investigation and potential discovery of new uses.

InChI:InChI=1/C10H11FO2/c1-2-13-10(12)7-8-5-3-4-6-9(8)11/h3-6H,2,7H2,1H3

Upstream product

• 64-17-5 ethanol 
• 451-82-1 (2-fluorophenyl)acetic acid 
• 103-36-6 ethyl 3-phenyl-2-propenoate 
• 326-63-6 2-(2-fluorophenyl)acetamide 
• 101-97-3 Ethyl 2-phenylethanoate 
• 1993-03-9 o-fluorophenylboronic acid 
• 105-36-2 ethyl bromoacetate 
• 326-62-5 2-fluorophenyl acetonitrile 
• 20511-20-0 ethyl p-methylcinnamate 
• 6048-06-2 ethyl-p-chlorocinnamate 

Downstream Products

• 50919-06-7 2-(2-fluorophenyl)ethanol 
• 100638-28-6 ethyl α-bromo-o-fluorophenylacetate 
• 405196-54-5 3-(2-fluorophenyl)glutaric acid 5-ethyl ester 
• 405196-55-6 4-ethoxycarbonyl-4-(fluorophenyl)butanoyl chloride 
• 75321-85-6 2-(2-fluorophenyl)acetaldehyde 
• 1219025-76-9 (E/Z)-ethyl 4-(2-fluorophenyl)-2-methylbut-2-enoate 
• 1219025-78-1 (E/Z)-4-(2-fluorophenyl)-2-methylbut-2-enol 
• 1219025-80-5 4-(2-fluorophenyl)-2-methylbutanol 
• 1219025-82-7 4-(2-fluorophenyl)-2-methylbromobutane 
• 1219025-84-9 8-(2-fluorophenyl)-2,2,6-trimethyl-4-(1H-1,2,4-triazol-1-yl)-octan-3-one 
• 1215910-00-1 2-cyclopentyl-2-(2-fluorophenyl)acetic acid 
• 1613403-70-5 (2E,4E)-ethyl 2-(2-fluorophenyl)-5-(4-methoxyphenyl)penta-2,4-dienoate 
• 1613403-38-5 ethyl 2-diazo-2-(2-fluorophenyl)acetate 

Relevant academic research and scientific papers

2-(Halogenated Phenyl) acetamides and propanamides as potent TRPV1 antagonists

A series consisting of 117 2-(halogenated phenyl) acetamide and propanamide analogs were investigated as TRPV1 antagonists. The structure–activity analysis targeting their three pharmacophoric regions indicated that halogenated phenyl A-region analogs exhibited a broad functional profile ranging from agonism to antagonism. Among the compounds, antagonists 28 and 92 exhibited potent antagonism toward capsaicin for hTRPV1 with Ki[CAP] = 2.6 and 6.9 nM, respectively. Further, antagonist 92 displayed promising analgesic activity in vivo in both phases of the formalin mouse pain model. A molecular modeling study of 92 indicated that the two fluoro groups in the A-region made hydrophobic interactions with the receptor.

Rapid Assembly of Saturated Nitrogen Heterocycles in One-Pot: Diazo-Heterocycle “Stitching” by N–H Insertion and Cyclization

Methods that provide rapid access to new heterocyclic structures in biologically relevant chemical space provide important opportunities in drug discovery. Here, a strategy is described for the preparation of 2,2-disubstituted azetidines, pyrrolidines, pi

Imidazole and Triazole Compounds, Their Use and Agents Containing The Same

The present invention relates to compounds of the formula I in which the variables have the meanings defined in the claims and in the description.

1-HETEROCYCLYL-1,5-DIHYDRO-PYRAZOLO[3,4-D] PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS PDE9A MODULATORS

The invention relates to novel 1,6-disubstituted pyrazolopyrimidinones, Formula (I) with Hc is a mono-, bi- or tricyclic heterocyclyl group, the ring members of which are carbon atoms and at least 1, preferably 1, 2 or 3, heteroatom(s), which are selected from the group of nitrogen, oxygen and sulphur, which is in the form of -S(O)r - with r being 0, 1 or 2, and - said heterocyclyl group is or comprises 1 non-aromatic, saturated, or partly unsaturated monocyclic ring which comprises at least 1 heteroatom as ring member and - said heterocyclyl group is bound to the scaffold by said 1 non- aromatic, saturated, or partly unsaturated monocyclic ring which comprises at least 1 heteroatom as ring member. According to one aspect of the invention the new compounds are for the manufacture of medicaments, in particular medicaments for the treatment of conditions concerning deficits in perception, concentration, learning or memory. The new compounds are also for the manufacture of medicaments for the treatment of Alzheimer's disease.

Pd-catalyzed synthesis of arylacetic acid derivatives from boronic acids

A palladium(0)-catalyzed cross-coupling reaction between arylboronic acids or esters and α-bromoacetic acid derivatives is described which allows the synthesis of various functionalized arylacetic acid derivatives under mild conditions.

ELECTRFLUORATION EN POSITION BENZYLIQUE DANS LE SULFOLANE

The use of sulfolane as a solvent instead of acetonitrile in the electrofluorination of benzylic derivatives 1, (R=H, Cl) gives greater yields of benzylic fluorides 2, since the formation of acetamide byproducts 4 is prevented.However, the parallel fluorination of the aromatic nucleus is not avoided under these conditions.

Reactions of Ethyl Cinnamates with Arylacetamides

Reactions of ethylcinnamates with arylacetamides gave the corresponding 2,6-diketo-3,4-diarylpiperidine (1a-o) in addition to the corresponding cinnamides (2a-o).The latter two are formed from the intermediates of the Claisen condensation of the reactants.On the other hand and contrary to the above results, condensation of p-methoxycinnamate with arylacetamides gave only p-methoxycinnamide in quantitative yields with the corresponding arylacetates.