326-75-0

Upstream product

• 348-62-9 4-chloro-2-fluorophenol 
• 79-11-8 chloroacetic acid 
• 366-99-4 3-fluoro-4-methoxyaniline 
• 452-09-5 4-chloro-2-fluoro-1-methoxybenzene 
• 105-36-2 ethyl bromoacetate 
• 1716-87-6 ethyl 2-(4-chloro-2-fluorophenoxy)acetate 

Downstream Products

• 1395103-26-0 2-[(4-chloro-2-fluorophenoxy)acetoxy](furan-2-yl)methyl-5,5-dimethyl-1,3,2-dioxaphosphinan-2-one 
• 1395103-31-7 2-(2-fluoro-4-chlorophenoxyacetoxy)(phenyl)methyl-5,5-dimethyl-1,3,2-dioxaphosphinan-2-one 
• 1395103-33-9 2-(4-chloro-2-fluorophenoxyacetoxy)(methyl)methyl-5,5-dimethyl-1,3,2-dioxaphosphinan-2-one 
• 1246091-47-3 C₈H₅Cl₂FO₂ 
• 1097935-59-5 2-methylpropan-2-aminium methyl (1-(2-(4-chloro-2-fluorophenoxy)acetoxy)ethyl)phosphonate 
• 1149644-85-8 O,O-dimethyl-1-(4-chloro-2-fluorophenoxyacetoxy)ethylphosphonate 
• 1149646-00-3 C₁₃H₁₇ClFO₆P 
• 1149647-28-8 C₁₄H₁₉ClFO₆P 
• 1149650-37-2 C₁₅H₂₁ClFO₆P 
• 1149651-15-9 C₁₄H₁₉ClFO₆P 
• 1097935-62-0 2-methylpropan-2-aminium methyl (1-(2-(4-chloro-2-fluorophenoxy)acetoxy)propyl)phosphonate 
• 1097935-65-3 2-methylpropan-2-aminium methyl (1-(2-(4-chloro-2-fluorophenoxy)acetoxy)butyl)phosphonate 
• 1097935-69-7 2-methylpropan-2-aminium methyl (1-(2-(4-chloro-2-fluorophenoxy)acetoxy)pentyl)phosphonate 
• 1097935-71-1 2-methylpropan-2-aminium methyl (1-(2-(4-chloro-2-fluorophenoxy)acetoxy)-2-methylpropyl)phosphonate 

Relevant academic research and scientific papers

The anti-invasive role of novel synthesized pyridazine hydrazide appended phenoxy acetic acid against neoplastic development targeting matrix metallo proteases

Neoplastic metastasis is a major process where tumor cells migrate from the primary tumor and colonize at other parts of our body to form secondary tumor. Cancer incidences are rising and novel anti-neoplastic compounds with new mechanism of actions are essential for preventing cancer related deaths. In the current examination, a novel series of pyridazine analogues 6a-l was synthesized and evaluated against metastatic neoplastic cells. Experimental data postulated compound 6j has potential cytotoxic efficacy with prolonged activity against various cancer cells, including A549, HepG2, A498, CaSki and SiHa cells. Moreover, compound 6j arrests the A549 migration and invasions markedly by counteracting matrix metalloproteinase (MMP)-2 and MMP-9 expressions. Also, compound 6j proved its potentiality against Dalton's solid lymphoma progression in-vivo by abridging MVD and MMP expressions. Compound 6j interacts with MMP-2 and MMP-9 by H- bond in-silico, thereby down regulates the MMPs action in tumourigenesis. Altogether, we concluded that compound 6j down regulates MMP-2 and MMP-9 and thereby impairs metastatic cancer cell migration and invasions which can be translated into a potent anti-neoplastic agent.

An Efficient One-Pot Synthesis of 2-(Aryloxyacetyl)cyclohexane-1,3-diones as Herbicidal 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors

4-Hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27, HPPD) is an important target for new bleaching herbicides discovery. As a continuous work to discover novel crop selective HPPD inhibitor, a series of 2-(aryloxyacetyl)cyclohexane-1,3-diones were rationally designed and synthesized by an efficient one-pot procedure using N,N′-carbonyldiimidazole (CDI), triethylamine, and acetone cyanohydrin in CH2Cl2. A total of 58 triketone compounds were synthesized in good to excellent yields. Some of the triketones displayed potent in vitro Arabidopsis thaliana HPPD (AtHPPD) inhibitory activity. 2-(2-((1-Bromonaphthalen-2-yl)oxy)acetyl)-3-hydroxycyclohex-2-en-1-one, II-13, displayed high, broad-spectrum, and postemergent herbicidal activity at the dosage of 37.5-150 g ai/ha, nearly as potent as mesotrione against some weeds. Furthermore, II-13 showed good crop safety against maize and canola at the rate of 150 g ai/ha, indicating that II-13 might have potential as a herbicide for weed control in maize and canola fields. II-13 is the first HPPD inhibitor showing good crop safety toward canola.

Synthesis and herbicidal activity of 2-(substituted phenoxyacetoxy)alkyl-5, 5-dimethyl-1,3,2-dioxaphosphinan-2-one containing fluorine

A series of novel 2-(substituted phenoxyacetoxy)alkyl-5,5-dimethyl-1,3,2- dioxaphosphinan-2-one bearing fluorine 5a-n and fluorine free 5o-q were designed and synthesized. The results of bioassay showed that some of the target compounds exhibited excellent herbicidal activities to Abutilon theophrasti, Brassica juncea, Amaranthus retroflexus and Eclipta prostrata in post-emergence treatment at a dosage of 150 g ai/ha. It could be found that the type and position of fluorine-containing group as X or Y on benzene ring had a very important effect on herbicidal activity. Compound 5l 2-[(2-chloro-4- fluorophenoxy)acetoxy](methyl)methyl-5,5-dimethyl-1,3,2-dioxaphosphinan-2-one showed notable herbicidal activity, with 100% inhibition against A. theophrasti and A. retroflexus; and compound 5m 2-(3-trifluoromethylphenoxyacetoxy)(methyl) methyl-5,5-dimethyl-1,3,2-dioxaphosphinan-2-one with 100% inhibition against A. theophrasti even at a dosage of 75 g ai/ha. Additional crop selectivity testing showed that compounds 5g 2-(3-trifluoromethylphenoxyacetoxy)(phenyl)methyl-5,5- dimethyl-1,3,2-dioxaphosphinan-2-one and 5l are safe to rice, corn, cotton, rape and wheat.