3260-90-0

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-3(2H)-benzofuranone is used as an intermediate in the synthesis of various pharmaceuticals for its potential to contribute to the development of new drugs with antibacterial, antifungal, antioxidant, and anti-inflammatory properties.
Used in Agrochemical Industry:
In the agrochemical industry, 4-Chloro-3(2H)-benzofuranone is utilized as a key component in the production of pesticides and disinfectants, capitalizing on its inherent antibacterial and antifungal properties to protect crops and control microbial growth.
Used in Disinfectant Production:
4-Chloro-3(2H)-benzofuranone is employed as an active ingredient in disinfectants for its ability to inhibit the growth of bacteria and fungi, thereby contributing to the sanitization of surfaces and reduction of disease transmission.
Used in Pesticide Formulation:
4-Chloro-3(2H)-benzofuranone is used as a constituent in pesticide formulations to protect agricultural produce from bacterial and fungal infections, ensuring crop health and increasing yield.

InChI:InChI=1/C8H5BrO2/c9-5-2-1-3-7-8(5)6(10)4-11-7/h1-3H,4H2

Upstream product

• 18362-30-6 2-chloro-6-hydroxybenzaldehyde 

Relevant academic research and scientific papers

A Hg(OTf)2-Catalyzed Enolate Umpolung Reaction Enables the Synthesis of Coumaran-3-ones and Indolin-3-ones

The potential of mercury catalysis has been extended to the arena of enolate umpolung reactions for the first time by the generation of enolonium species via Hg(OTf)2-catalyzed N-oxide addition to alkynes. The enolonium species formed can undergo intramolecular nucleophilic attack by hydroxyl or amino groups, leading to the synthesis of various coumaran-3-ones and indolin-3-ones.

Catalytic synthesis method of 3-benzofuranone compound

The invention discloses a catalytic synthesis method of a 3-benzofuranone compound. The catalytic synthesis method comprises the following steps: dissolving a 2-acetenyl phenol derivative into a solvent dichloromethane at normal temperature and normal pressure according to a molar volume ratio of the 2-acetenyl phenol derivative to the dichloromethane of 1:5mmol/mL, so as to obtain a dichloromethane solution of the 2-acetenyl phenol derivative; then adding mercury trifluoromethanesulfonate and pyridine-N-oxide into a dichloromethane solution of the 2-ethynylphenol derivative, wherein the molaramounts of mercury trifluoromethanesulfonate and pyridine-N-oxide are respectively 5% and 120% of the molar amount of the 2-ethynylphenol derivative; and then performing stirring for 1 hour at room temperature, and performing reacting to generate the 3-benzofuranone compound. The market price of the catalyst mercury trifluoromethanesulfonate used in the catalytic synthesis method is lower than 30yuan/g, the cost is low, the operation is simple, the reaction time is short, the reaction conditions are mild, the reaction yield is high, and the yield can reach 91.0-96.0%.