326019-65-2Relevant academic research and scientific papers
8-Mercaptoguanine-based inhibitors of Mycobacterium tuberculosis dihydroneopterin aldolase: synthesis, in?vitro inhibition and docking studies
Czeczot, Alexia de Matos,Roth, Candida Deves,Ducati, Rodrigo Gay,Pissinate, Kenia,Rambo, Raoní Scheibler,Timmers, Luís Fernando Saraiva Macedo,Abbadi, Bruno Lopes,Macchi, Fernanda Souza,Pestana, Víctor Zajaczkowski,Basso, Luiz Augusto,Machado, Pablo,Bizarro, Cristiano Valim
, p. 847 - 855 (2021/03/29)
The dihydroneopterin aldolase (DHNA, EC 4.1.2.25) activity of FolB protein is required for the conversion of 7,8-dihydroneopterin (DHNP) to 6-hydroxymethyl-7,8-dihydropterin (HP) and glycolaldehyde (GA) in the folate pathway. FolB protein from Mycobacteri
Structure-based design and development of functionalized mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from staphylococcus aureus
Dennis, Matthew L.,Chhabra, Sandeep,Wang, Zhong-Chang,Debono, Aaron,Dolezal, Olan,Newman, Janet,Pitcher, Noel P.,Rahmani, Raphael,Cleary, Ben,Barlow, Nicholas,Hattarki, Meghan,Graham, Bim,Peat, Thomas S.,Baell, Jonathan B.,Swarbrick, James D.
, p. 9612 - 9626 (2015/02/02)
6-Hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK), an enzyme from the folate biosynthesis pathway, catalyzes the pyrophosphoryl transfer from ATP to 6-hydroxymethyl-7,8-dihydropterin and is a yet-to-be-drugged antimicrobial target. Building on ou
