32605-98-4

Basic information

• Product Name: 3-chloro-N-cyclohexylaniline
• CAS NO: 32605-98-4
• Molecular Weight: 209.719
• Mol File: 32605-98-4.mol

Chemical Properties

• CAS DataBase Reference: 3-chloro-N-cyclohexylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-N-cyclohexylaniline(32605-98-4)
• EPA Substance Registry System: 3-chloro-N-cyclohexylaniline(32605-98-4)

Safety Data

• Hazardous Substances Data: 32605-98-4(Hazardous Substances Data)

Upstream product

• 127820-39-7 tris(4-chlorophenyl)sulfonium trifluoromethanesulfonate 
• 108-91-8 cyclohexylamine 
• 729610-42-8 4-chloro-2-(cyclohexylamino)benzoic acid 

Downstream Products

• 32695-14-0 N-Cyclohexyl-bernsteinsaeure-m-chloranilid 

Relevant articles and documents

Transition-Metal-Free N-Arylation of Amines by Triarylsulfonium Triflates

A simple and efficient method for transition-metal-free N-arylation of various amines by triarylsulfonium triflates is described. Both aliphatic and aromatic amines were smoothly converted at 80 °C in the presence of tBuOK or KOH to give the corresponding mono N-arylated products in good to high yields. The molar ratios of the reactants and the choice of bases had a big effect on the reaction. When a large excess of [Ph3S][OTf] and tBuOK were employed for primary amines under the standard conditions, the bis(N-phenyl) products were predominantly formed. This method was also applicable to the synthesis of bioactive N-phenyl amino acid derivatives. The control experiments, the deuterium labelling study, and the presence of regioisomers of N-arylated products when using 4-substituted triarylsulfonium triflates suggested that the reaction might proceed through an aryne intermediate. The present protocol demonstrated that triarylsulfonium salts are versatile arylation reagents in the construction of CAr?N bonds.

Two Component Recyclable Heterogeneous Catalyst, Process for Preparation Thereof and its Use for Preparation of Amines

The invention describes the development of highly efficient, recyclable two component system, CuAl-hydrotalcite/rac 1,1′-Binaphthalene-2,2′-diol catalytic system for the N-alkylation of electron deficient aryl chlorides in presence of potassium carbonate as a base at room temperature in 3-6 h, wherein the process is provided for the preparation of various secondary amines via C—N coupling reaction of aliphatic amines(aliphatic open chain, acyclic, benzyl amines and heterocyclic amines) with various aryl chlorides.