3261-08-3

Upstream product

• 1218-24-2 5'-chloro-2'-hydroxychalcone 
• 6077-40-3 2'-acetoxy-5'-chlorochalcone 
• 1350477-58-5 4-chloro-2-(3-phenylpropynoyl)phenol 
• 100-52-7 benzaldehyde 
• 1262020-27-8 4-chloro-2-(1-hydroxy-3-phenylprop-2-yn-1-yl)phenol 
• 635-93-8 5-chlorosalicyclaldehyde 
• 536-74-3 phenylacetylene 
• 1262020-34-7 (Z)-2-benzylidene-5-chloro-2,3-dihydrobenzofuran-3-ol 
• 131948-09-9 2'-acetoxy-α-bromo-5'-chloro-β-methoxydihydrochalcone 
• 6344-95-2 2,3-dibromo-1-(5-chloro-2-hydroxy-phenyl)-3-phenyl-propan-1-one 

Relevant academic research and scientific papers

One-pot Synthesis of Aurones through Oxidation-cyclization Tandem Reaction Catalyzed by Copper Nanoparticles Catalyst

Aurones were synthesized through an oxidation-cyclization tandem reaction of 2-(1- hydroxyprop-2-ynyl)phenols catalyzed by copper nanoparticles (Cu NPs) with bipyridine as the ligand. In the reaction, oxygen worked as a green and mild oxidant to give the best results. Cu NPs were dually activated by bipyridine ligand and water, and showed highly efficient catalytic activities to the oxygen oxidation and the cylization to give aurones and flavonoids.

An efficient synthesis of aurone derivatives by the tributylphosphine-catalyzed regioselective cyclization of o-alkynoylphenols

An organocatalytic regioselective synthes is of aurones from o-alkynoylphenols was achieved. A catalytic amount of tributylphosphine select ively induced the 5-exo cyclization of o-alkynoylphenols under ambient conditions leading to aurone derivatives in high to excellent yields.

Water-promoted, silver-phosphine complex-catalyzed stereoselective cyclization of 2-(1-Hydroxy-3-arylprop-2-ynyl)phenols leading to a highly efficient approach to aurones

Silver-phosphine complexes can be utilized as highly efficient catalysts for the cyclization of 2-(1-hydroxy-3-arylprop-2-ynyl)phenols (1) to give product 2, key intermediates to synthesize aurones (4), with good yields and stereoselectivities in water-to

FLAVONE FORMATION IN THE WHEELER AURONE SYNTHESIS

Dihydrochalcones, formed by bromomethylation of the side-chain of 2'-acetoxychalcones, were found to produce minor quantities of flavones as well as the major product, aurones, when cyclized by aqueous ethanolic sodium hydroxide.The yields of flavone increased with increasing base concentration.The optimum concentration of hydroxide for aurone formation was below 1percent.Greatly diminished yields of O-heterocycles were obtained when a nitro substituent was introduced para to the cyclizing 2'-oxy function.