326498-83-3Relevant academic research and scientific papers
Intermolecular asymmetric carboesterification of alkenes by using chiral amine auxiliaries under o2: Synthesis of enantioenriched α-methylene-γ-lactones through chloropalladation of alkynes
Zhang, Zhenming,Wu, Wanqing,Liao, Jianhua,Li, Jianxiao,Jiang, Huanfeng
, p. 6708 - 6712 (2015)
Herein, the first example of chloropalladation-initiated asymmetric intermolecular carboesterification of alkenes with alkynes by using chiral amine auxiliaries is reported. The use of (1S,2S)-N1,N1-dimethylcyclohexane-1,2-diamine auxiliaries is essential for providing α-methylene-γ-lactones products in moderate to high yields and excellent enantioselectivities at room temperature. Moreover, the chiral amine auxiliaries can be readily removed by hydrolysis during the reaction process to keep the absolute configuration. This oxygen- and water-promoted asymmetric reaction opens a new window to study asymmetric processes in halopalladation reactions.
A convenient synthesis of chiral 2-alkynyl-1,3-oxazolines
Cevallos, Alexandre,Rios, Ramon,Moyano, Albert,Pericas, Miquel A.,Riera, Antoni
, p. 4407 - 4416 (2007/10/03)
A general, high-yielding, two-step synthesis of chiral 2-alkynyl-1,3-oxazolines starting from 2-alkynoic acids and 2-aminoalcohols is disclosed. (C) 2000 Published by Elsevier Science Ltd.
