32684-57-4

Upstream product

• 32684-58-5 6-methoxy-3-phenyl-4H-chromen-4-one 
• 52122-86-8 2,5-dihydroxy-deoxybenzoin 
• 109-94-4 formic acid ethyl ester 
• 103-82-2 phenylacetic acid 
• 123-31-9 hydroquinone 
• 68-12-2 N,N-dimethyl-formamide 
• 490-78-8 2,5-Dihydroxyacetophenone 
• 310411-89-3 3-iodo-6-methoxy-4H-1-benzopyran-4-one 
• 150-78-7 1,4-dimethoxybezene 
• 103-80-0 phenylacetyl chloride 
• 80427-38-9 1-(2-hydroxy-5-methoxyphenyl)-2-phenylethan-1-one 

Downstream Products

• 32684-58-5 6-methoxy-3-phenyl-4H-chromen-4-one 
• 109588-93-4 5,6-dihydroxy-3-phenyl-chromen-4-one 
• 856791-76-9 6-hydroxy-4-oxo-3-phenyl-4H-chromene-5-carbaldehyde 

Relevant academic research and scientific papers

Development of 3-alkyl-6-methoxy-7-hydroxy-chromones (AMHCs) from natural isoflavones, a new class of fluorescent scaffolds for biological imaging

Starting from 7-hydroxyisoflavones, we developed a new class of fluorescent scaffolds, 3-alkyl-6-methoxy-7-hydroxy-chromones (AMHCs, MW ～ 205.19, λab ～ 350 nm, λem ～ 450 nm) via a trial and error process. AMHCs have the advantages of being a small molecular moiety, having strong fluorescence in basic buffers, reasonable solubility and stability, non-toxicity, and are conveniently linked to pharmacophores. AMHCs were successfully used in fluorescence microscopy imaging of cells and tissues. This journal is

Development of a general approach to the synthesis of a library of isoflavonoid derivatives

Isoflavonoids are a class of organic compounds that act primarily as antioxidants. They are produced almost exclusively by various members of the bean family including soybeans, tofu, peanuts, chick peas, and alfalfa. The antioxidant characteristics that isoflavonoids exhibit help hinder the progression of certain cancers, primarily breast, prostate, and colon cancer. We have developed a three-five step synthesis for obtaining a suite of isoflavonoid derivatives. The synthesis involves an enamine formation, a ring closure and halogenation, a Suzuki coupling, and finally a global deprotection to obtain the respective isoflavonoid derivatives.

Expedient Synthesis of Polyhydroxyisoflavones

A general and direct synthesis of polyhydroxy isoflavones (3-phenyl-4H-1-benzopyran-4-ones) starting from the corresponding unprotected phenols and arylacetic acids is described.The aryl rings may carry additional alkyl, methoxy and/or halogeno groups.Intermediate polyhydroxydeoxybenzoins (1,2-diphenylethanones) can also be isolated in good yields.