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Usage

Uses

Used in Pharmaceutical Applications:
Ethanone, 1-(2-hydroxy-5-methoxyphenyl)-2-phenylis used as a potential therapeutic agent for its antioxidant and anti-inflammatory properties, which may contribute to the treatment or management of various conditions where these properties are beneficial.
Used in Medical Research:
In the field of medical research, Ethanone, 1-(2-hydroxy-5-methoxyphenyl)-2-phenylis utilized as a subject of study to understand its interactions with biological receptors and enzymes, aiming to uncover its potential role in influencing their activity and the implications for therapeutic interventions.
Used in Drug Development:
Ethanone, 1-(2-hydroxy-5-methoxyphenyl)-2-phenylis considered in drug development for its potential to be formulated into new medications, leveraging its antioxidant and anti-inflammatory effects, as well as its possible receptor and enzyme interactions, to address specific medical needs.

Upstream product

• 2308-20-5 4-methoxyphenyl 2-phenylacetate 
• 103-80-0 phenylacetyl chloride 
• 103-82-2 phenylacetic acid 
• 150-76-5 4-methoxy-phenol 
• 150-78-7 1,4-dimethoxybezene 
• 7446-70-0 aluminium trichloride 
• 60-29-7 diethyl ether 

Downstream Products

• 176643-17-7 4-methoxy-2-phenylacetylphenol ethylene acetal 
• 176642-62-9 ethyl 4-methoxy-2-phenylacetylphenoxyacetate 
• 176643-18-8 ethyl 4-methoxy-2-phenylacetylphenoxyacetate ethylene acetal 
• 32684-58-5 6-methoxy-3-phenyl-4H-chromen-4-one 
• 109441-39-6 6-methoxy-2-methyl-3-phenyl-chromen-4-one 
• 1300581-33-2 2-(Bromomethyl)-6-methoxy-3-phenyl-4H-chromen-4-one 
• 1300583-19-0 2-((6-Amino-9H-purin-9-yl)methyl)-6-methoxy-3-phenyl-4H-chromen-4-one 
• 115272-98-5 6-hydroxy-2-methyl-4-oxo-3-phenyl-4H-chromene-5-carbaldehyde-(2,4-dinitro-phenylhydrazone) 
• 113013-84-6 5,6-diacetoxy-2-methyl-3-phenyl-chromen-4-one 
• 109396-48-7 6-hydroxy-2-methyl-4-oxo-3-phenyl-4H-chromene-5-carbaldehyde 
• 374763-64-1 6-hydroxy-2-methyl-3-phenyl-chromen-4-one 
• 32684-57-4 6-hydroxy-3-phenyl-4H-chromen-4-one 

Relevant academic research and scientific papers

Synthesis of 7-hydroxy-6H-naphtho[2,3-c]coumarinviaa TsOH-mediated tandem reaction

A concise and efficient method for the synthesis of 7-hydroxy-6H-naphtho[2,3-c]coumarin using available 1-(2-hydroxyphenyl)-2-phenylethanone and Meldrum's acid has been developed. This transformation involved a tandem aldol reaction/lactonization/Friedel-Crafts reaction to form a lactone ring and a benzene ring. It showed high atom economy with water and acetone as the byproducts. Mechanism studies demonstrated two roles of Meldrum's acid: (i) as the reagent for the tandem reaction, and (ii) as the catalyst for the Friedel-Crafts reaction. Moreover, the hydroxyl group of 7-hydroxy-6H-naphtho[2,3-c]coumarin was further functionalized efficiently by arylethynyl, aryl, and cyano groups to furnish D-π-A compounds with excellent fluorescence emissions (ΦF= 0.14-0.78).

Development of 3-alkyl-6-methoxy-7-hydroxy-chromones (AMHCs) from natural isoflavones, a new class of fluorescent scaffolds for biological imaging

Starting from 7-hydroxyisoflavones, we developed a new class of fluorescent scaffolds, 3-alkyl-6-methoxy-7-hydroxy-chromones (AMHCs, MW ～ 205.19, λab ～ 350 nm, λem ～ 450 nm) via a trial and error process. AMHCs have the advantages of being a small molecular moiety, having strong fluorescence in basic buffers, reasonable solubility and stability, non-toxicity, and are conveniently linked to pharmacophores. AMHCs were successfully used in fluorescence microscopy imaging of cells and tissues. This journal is

An improved synthesis of hydroxy aryl ketones by fries rearrangement with methanesulfonic acid/methanesulfonic anhydride

Methanesulfonic acid treated with methanesulfonic anhydride effectively mediates the Fries rearrangement of aryl esters to give hydroxy aryl ketones with high yields. Georg Thieme Verlag Stuttgart · New York.

NOVEL KINASE MODULATORS

The present invention provides PI3K protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.

Studies on the Friedel-Crafts Reaction. XVI, Preparation of Isomeric 2-Acyl- and 3-Acyl-4-methoxy Phenols

Acylation of 4-methoxy phenol according to Friedel and Crafts, as well as the rearrangement of its esters according to Fries lead always to 2-acyl-4-methoxy phenols or to their demethylated compounds.The unknown 3-acyl-4-methoxyphenols were prepared in two steps: First, the ester is acylated with the corresponding acyl chloride and SnCl4 in nitromethane.In the second step the resulting ketoesters are hydrolysed.This is a general method.The yields of meta-acylphenols are between 40 and 90percent.The isomeric 2-acyl-4-methoxyphenols which were partly unknown or accessible only in low yields have also been prepared for comparative spectral studies (UV, IR, NMR, MS) of ortho- and meta-acylphenols. - Keywords: Friedel-Crafts acylation; Fries rearrangement; Ketoesters; Spectral data