32689-62-6

Upstream product

• 4530-20-5 BOC-glycine 
• 27894-50-4 methyl (2S)-2-amino-6-{[(benzyloxy)carbonyl]amino}hexanoate hydrochloride 
• 66866-43-1 N-(t-butoxycarbonyl)glycyl i-butyl carbonate 
• 24498-31-5 (S)-methyl 2-amino-6-(benzyloxycarbonylamino)hexanoate 
• 89711-08-0 N-(t-butoxycarbonyl)glycinal 
• 2389-45-9 Boc-Lys(Z)-OH 
• 73548-77-3 Boc-L-Lys(Z)-OMe 
• 27454-43-9 N^ε-tosyl-L-lysine methyl ester hydrochloride 
• 99547-40-7 N^α-tert-butoxycarbonylglycyl-N^ε-tosyl-L-lysine methyl ester 

Downstream Products

• 61272-64-8 (S)-methyl 2-(2-aminoacetamido)-6-(benzyloxycarbonylamino)hexanoate 
• 248605-41-6 cyclo (Gly-L-Lys(Z)-L-Val-3(S)-aminododecanoyl-) 
• 172941-85-4 cyclo (Gly-L-Lys(Z)-L-Val-3(R)-aminododecanoyl-) 
• 946424-93-7 Boc-D-Asp(OBz)-Ala-Gly-Lys(Z)-NHMe 
• 156310-90-6 Boc-Ala-Gly-Lys(Z)-NHMe 
• 156310-89-3 Boc-Gly-Lys(Z)-NHMe 
• 32769-95-2 Boc-Gly-L-Lys(Z) 

Relevant academic research and scientific papers

Heterovalent inhibitors targeting N-end Rule Pathway and its use

An alkali-soluble polymer resin compound of formula 1 a including N-end Rule pathway inhibitors disclosure the composition. According to type 1 and type 2 herein each compounds recognizing substrate UBR box and a ClpS box a mammal having two tolerance N-e

Conjugated TLR7 and/or TLR8 and TLR2 polycationic agonists

A conjugated compound of Formula I: Q-Z—R4 wherein Q is a TLR7 and/or TLR8 agonist and Z—R4 is a TLR2 agonist, the conjugated compound being chosen among compounds of Formula II:

Conjugated TLR7 and/or TLR8 and TLR2 polycationic agonists

The present invention relates to a conjugated compound of Formula I : Q-Z-R4 wherein Q is a TLR7 and/or TLR8 agonist and Z-R4 is a TLR2 agonist, said conjugated compound being chosen among compounds of Formula II :

The effect of Glu→ Asp substitution on a 310type fold in BoC-(D)-GlU1-Ala2-Gly3-LyS4-NHMe

The solution conformation of the peptide Boc-(D)-Asp1-Ala 2-Gly3-Lys4-NHMe based on NMR studies is compared with its (D)-Glu1 analog reported earlier. Results establish that (D)-Asp analog is devoid o

Rhodopeptins, novel cyclic tetrapeptides with antifungal activities from Rhodococcus sp.. III. Synthetic study of rhodopeptins

Total syntheses of cyclo (-Gly-L-Lys-L-Val-(R)-3-aminododecanoyl-); LV9nA and its diastereomer cyclo (-Gly-L-Lys-L-Val-(S)-3-aminododecanoyl-); LV9nB, congeners of rhodopeptin B5 on β-amino acid moiety, were achieved. The β-amino acid moiety was prepared as a racemate by the thermal Michael addition of an amine to α,β-unsaturated ester. The racemic β-amino acids were converted to their L-Valylamide derivatives and the obtained diastereomers were separated. Coupling of both diastereomers, L-Val-β-amino acids with Gly-L-Lys gave linear tetrapeptides, and tetrapeptides were cyclized by diphenylphosphoryl azide (DPPA) method between C-terminus of β-amino acid and N-terminus of Gly to give cyclic tetrapeptides. The deprotected cyclic tetrapeptides, LV9nA and LV9nB, both exhibited almost the same antifungal activity as the naturally obtained rhodopeptins. Furthermore, comparison of the 1H NMR spectra of two congeners and rhodopeptin B5 suggested that the stereochemistry of β-amino acid moiety in natural rhodopeptin B5 has (R)-configuration.

Stable type II' reverse turn - 310 helix conformation of Boc-D-Glu-Ala-Gly-Lys-Ala-Leu-OMe in apolar solvents

The solution conformation of the title compound, based on one and two dimensional NMR techniques in CDCl3 and (CD3)2SO at 500 MHz, has been deduced as a 310 helix initiated by an electrostatically locked type II' reverse turn.

Selective Removal of Electron-Accepting p-Toluene- and Naphthalenesulfonyl Protecting Groups for Amino Function via Photoinduced Donor-Acceptor Ion Pairs with Electron-Donating Aromatics

When N-tosylamines (3a, 3b, 7, 17a, 17b, 21, 23) in aqueous ethanol were irradiated with a high-pressure mercury lamp in the presence of an electron-donating aromatic such as 1,2- (6) and 1,4-dimethoxybenzenes (10) and 1,5-dimethoxynaphthalene (14) and a reductant (sodium borohydride, ascorbic acid, ammonia borane, hydrazine), a photochemical detosylation proceeded quite easily to give the corresponding amines (4a, 4b, 8, 18a, 18b, 22, 24) in the high yields.On irradiation in the presence of 10 and sodium borohydride, N-(naphthalenesulfonyl)phenethylamine (19) also gave 4a.Mechanistic studies based on fluorescence quenching, quantum yield measurement, and free energy change calculation show that this photoreaction involves an electron transfer from an electron-donating aromatic to an electron-accepting sulfonamide.A preliminary application for the synthesis of lysine peptides was also described.