326902-29-8

Upstream product

• 100-51-6 benzyl alcohol 
• 220623-25-6 (1R,2S,5S,6R)-3-aza-3-<(tert-butyl)oxycarbonyl>-6-methoxycarbonylbicyclo<3.1.0>hexyl-2-carboxylic acid 
• 326902-26-5 benzyl (1R,2S,5S,6R)-3-aza-3-(tert-butyloxycarbonyl)-6-(methoxycarbonyl)bicyclo[3.1.0]hexane-2-carboxylate 

Downstream Products

• 326902-42-5 3-{3-[3-(2,2-dimethyl-propionyl)-6-methoxycarbonyl-3-aza-bicyclo[3.1.0]hexane-2-carbonyl]-6-methoxycarbonyl-3-aza-bicyclo[3.1.0]hexane-2-carbonyl}-3-aza-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid 2-benzyl ester 6-methyl ester 
• 326902-37-8 (1R,2S,5S,6R)-3-[(1R,2S,5S,6R)-3-(2,2-Dimethyl-propionyl)-6-methoxycarbonyl-3-aza-bicyclo[3.1.0]hexane-2-carbonyl]-3-aza-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid 2-benzyl ester 6-methyl ester 
• 326902-32-3 benzyl (1R,2S,5S,6R)-3-aza-3-(2,2-dimethylpropanoyl)-6-(methoxycarbonyl)bicyclo[3.1.0]hexane-2-carboxylate 

Relevant academic research and scientific papers

Poly-L-proline type II peptide mimics based on the 3-azabicyclo[3.1.0]hexane system

This paper describes conformational studies of proline-templated amino acids (PTAAs) based on the 3-azabicyclo[3.1.0]hexane system as well as conformational studies on short peptides composed of these PTAAs. NOE data, coupling constants, and molecular modeling are consistent with a flattened boat conformation for monomeric and oligomeric residues based on this bicyclic system. NMR studies on dimeric and trimeric oligomers are consistent with a populated poly-L-proline type II conformation in CDCl3 and D2O. Solution studies and molecular modeling predicts φ ～ -70°, ψ ～ 131°, χ1 ～ -57°, and χ2 ～ -158° for oligomeric residues.