326919-53-3

Upstream product

• 42205-33-4 ethyl 3-(4-bromophenyl)-2-cyanoacrylate 
• 504-02-9 1,3-cylohexanedione 
• 1122-91-4 4-bromo-benzaldehyde 
• 105-56-6 ethyl 2-cyanoacetate 
• 109-77-3 malononitrile 

Relevant academic research and scientific papers

Pyran Derivatives: Anti-Breast Cancer Activity and Docking Study

Four novel pyran derivatives 1–4 are synthesized and characterized by IR, 1H NMR, HRMS, and single crystal X-ray data. Anticancer activity of the compounds is tested against four human breast cancer cells (HCC1937, HCC70, MDA-MB-436, and BT474)

Efficient asymmetric synthesis of 4H-chromene derivatives through a tandem michael addition-cyclization reaction catalyzed by a salen-cobalt(II) complex

The asymmetric synthesis of 2-amino-5-oxo-5,6,7,8-tetrahydro-4H-chromene derivatives was achieved through a tandem Michael addition-cyclization reaction of easily available cyclohexane-1,3-dione and ethyl 2-cyano-3-phenylacrylates. Moderate to good yields (up to 81%) and high enantioselectivities (up to 89%ee) were obtained with a chiral salen-cobalt(II) complex. This process was air tolerant and easily performed, which provides an efficient method for the synthesis of chiral 4H-chromene derivatives. The asymmetric synthesis of 2-amino-5-oxo-5,6,7,8-tetrahydro-4H-chromene derivatives was achieved through a tandem Michael addition-cyclization reaction of easily available cyclohexane-1,3-dione and ethyl 2-cyano-3-phenylacrylates catalyzed by a chiral salen-cobalt(II) complex with moderate to good yields (up to 81%) and high enantioselectivities (up to 89%ee).