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Factory Chlorogenic acid 10% -95% 98% 99% in stock CAS NO.327-97-9
Cas No: 327-97-9
No Data 1 Gram 1 Metric Ton/Month Shaanxi Mingqi Chemical Co., Ltd Contact Supplier
Green coffee bean extract
Cas No: 327-97-9
USD $ 1.0-1.0 / Kilogram 25 Kilogram 5000 Kilogram/Month EXCELLENT HEALTH PRODUCTS CO.,LTD Contact Supplier
Good quality with low price Chlorogenic acid
Cas No: 327-97-9
No Data 1000 Kilogram 500 Metric Ton/Month Lonwin Chemical Group Limited Contact Supplier
Chlorogenic acid
Cas No: 327-97-9
USD $ 800.0-1000.0 / Kilogram 1 Kilogram 5000 Metric Ton/Day Kono Chem Co.,Ltd Contact Supplier
Pharma Grade Chlorogenic Acid Honeysuckle Flower Extract
Cas No: 327-97-9
No Data 1 Kilogram 1000 Kilogram/Month Changsha Staherb Natural Ingredients Co.,Ltd Contact Supplier
Chlorogenic acid
Cas No: 327-97-9
USD $ 596.22-596.22 / Kilogram 1 Kilogram 100 Kilogram/Month Wuhan ZeShanCheng Biomedical Technology Co., Ltd. Contact Supplier
Best Price Chlorogenic acid
Cas No: 327-97-9
USD $ 33.0-36.0 / Kilogram 1 Kilogram 100 Metric Ton/Month Salus Nutra Inc Contact Supplier
Chlorogenic acid
Cas No: 327-97-9
No Data 1 Kilogram 50~100 Kilogram/Month Shanghai PurityPE Biotechnology Co., Ltd. Contact Supplier
E-0075 Chlorogenic Acid
Cas No: 327-97-9
USD $ 800.0-800.0 / Gram 100 Gram Metric Ton/Day shanghai Tauto Biotech Co., Ltd Contact Supplier
High quality Chlorogenic acid in bulk supply
Cas No: 327-97-9
No Data No Data No Data DB BIOTECH CO., LTD Contact Supplier

327-97-9 Usage

Purification Methods

Crystallise the acid from water and dry it at 110o. [Beilstein 10 H 537, 10 I 271, 10 II 378, 10 III 2408, 10 IV 2259.]

Chemical Properties

white to slightly yellowish-beige powder

Category

Toxic substances

Fire extinguishing agent

Water, carbon dioxide, dry powder, sand

Uses

A major component of green coffee the extracts of which promote weight loss in overweight and obese people. Chlorogenic Acid is an important intermediate in lignin biosynthesis. Chlorogenic Acid is an antioxidant and an inhibitor of the tumor promoting activity of phorbol ester. It has protective effect against streptozotocin-nicotinamide generated oxidative stress induced diabetes and may also pr otect against cardiovascular disease.

Pharmacological action

Chlorogenic acid is also called "green" auspicious acid, tannins "coffee", "coffee tannic acid", is a plant produce a styrene acrylic compounds through shikimic acid hitches in aerobic respiration process.It is coffee acyl quinic acid derivatives.The oxidation resistance is strong, and also has the anti HIV, anti tumor cells, antibacterial, improve central excited, cholagogue function.It has teratogenic, allergy and regulate the activity of cytochrome P450 ligase, and other functions.It is widely exist in more content honeysuckle plants. It is obtained by the water needle crystal, and it is the hemihydrate, when 110 ℃ it is to hydrate. Melting point is 208 ℃, [a] D25 33.5 ° (water, C = 1), K = 2.2 x 10-3 (27 ℃).It is weak acidity and convergence. When 25 ℃ , the solubility in water is 4%, easily soluble in hot water, but soluble in ethanol, acetone, slightly soluble in ethyl acetate, insoluble in chloroform, ether and carbon disulfide. It is azeotropic with concentrated hydrochloric acid and come to blue dye. It can make the bromine water fade, It is azeotropic with strong hydrogen iodide and obtain benzoic acid, It is obtained phenol by thermal decomposition together with water at 230 ℃, It decomposite to caffeic acid and quinic acid with dilute hydrochloric acid, and caffeic acid and quinic acid with dilute alkali at room temperature. Chlorogenic acid and its isomer different chlorogenic acid and green chlorogenic acid are in fruits of dicotyledonous plants, leaves, and other organizations,which is an important factor for plant metabolism. Chlorogenic acid has good biological activity, the transparent acid enzyme and inhibition of glucose-6-phosphatase, free radical lipid perxidation qing mutagenesis resistance and cardiovascular crown reinforcement, special efficacy in lipid-lowering, both anti-bacterial anti-virus, protecting liver cholagogic.
Chlorogenic acid as the condensation product of caffeic acid and quinic acid, is blue when meeting with iron, which is similar to tannins , but not precipitated with protein, so no convergence. Caffeic acid and chlorogenic acid has the wide bacteriostasis, but can be inactivated protein in the body. This product is similar to caffeine, oral or intraperitoneal injection, can improve the rat central excitability. Oral the drug of chlorogenic acid and coffee acid can increase the amount of hydrochloric acid secretion in the stomach, and can make slow pulse, and quinic acid is not. Chlorogenic acid could significantly increase small intestine peristalsis on the rat or mouse. Chlorogenic acid, caffeic acid and quinic acid can increase the tension of rat uterus, this function can be cancelled by papaverine, while atropine can't influence. Caffeic acid, chlorogenic acid, also can promote bile secretion in rats. On the specimens of rabbit ileum in vitro, this product can enhance the effect of adrenaline, but has no effect on blood glucose of adrenaline.

The inhibitory effect on hyaluronidase and glucose - 6 - phospha

Hyaluronic cranberry (HAase) is one of the cracking mucopolysaccharide enzymes, can catalyze hyaluronic acid (HA) decomposition,which is in relation to the permeability of vascular system and inflammation. HA is a mucopolysaccharide, which is composed of uronic acid and acetyl glucosamine, having a variety of functions, such as heal, make the skin wetting health, lubricating joints and prevent inflammation, etc. 3, 5-2 coffee acyl quinic acid (artichoke acid) and chlorogenic acid found in the ethyl acetate extract from the narrow assists cone flower (Echinacea amgustifolia DC) roots have stronger inhibitory effect of HAase activated. Animal in vitro studies have demonstrated that chlorogenic acid can not reversible inhibition of glucose-6-hydrolysis of phosphatase, reduce liver glycogen decomposition and exogenous glucose absorption. Animal studies have shown that the use of chlorogenic acid can reduce high blood sugar spikes caused by the use of glucagon (glycogenolysis). Therefore, chlorogenic acid can lower blood sugar level, improve the liver glucose-6-phosphoric acid and the concentration of hepatic glycogen.

Uses

antioxidant, free radical scavenger

Uses

It has broad antibacterial effect, advantageous bravery, hemostatic, increase white blood cell and antiviral effect, the effect of the blood clotting and bleeding time is shortened. It is used in the treatment of upper respiratory tract infection, anti-inflammatory and antipyretic, cool blood heat dissipation. Used as pharmaceutical raw materials and intermediates. clearing heat and removing toxicity, cold wind heat, broad-spectrum antimicrobial properties, having obvious inhibitory effect to hemolytic streptococcus, dysentery rod gas and salmonella typhi bacteria

Toxicity grading

toxication

Storage and transport properties

Low temperature warehouse, ventilated, dry

Preparation method

It can be obtained by (1S)-1-ethoxyformyloxy-3-cis-[3,4-dihydroxy-anti-cinnamoyl oxygen radicals]-4'-anti-5'-anti-dihydroxy cyclohexane-γ-methyl formate with barium hydroxide in methanol catalytic hydrolysis, or by the segregation from green coffee beans.

The character of molecular structure

Chlorogenic acid is formed by caffeic acid and quinic acid, and the molecular structure has ester bond, unsaturated double bond and polyphenol unstable part of the three. In the process of extracted from plants, chlorogenic acid often happen by hydrolysis and intramolecular ester base migration isomerization . Due to the special structure of chlorogenic acid, it can extract from plants by the polarity solvent such as ethanol, acetone, methanol. But due to the instability of chlorogenic acid itself, extraction can not be in high temperature, strong light and heat for a long time. Chlorogenic acid liquid were placed in brown bottle, refrigerator (2 ℃) to save to be the most stable.

Acute toxicity

Abdominal cavity-rat LDL0:4000 mg/kg

Toxicity

Chlorogenic acid is sensitive to people, can cause asthma, dermatitis, but no this reaction to the oral of chlorogenic acid. It can be active no sensitization substances by small intestinal secretions convertion to. The toxicity of chlorogenic acid is very small, LD50 is greater than 1 g/kg to young rats, intraperitoneal injection of greater than 0.25 g/kg.

Flammability hazard characteristics

Combustible; Release acrid smoke fire

Chemical property

Hemihydrate is needle crystal (water). When 110 ℃, it become to anhydrous compounds. Melting point: 208 ℃, [alpha] 20D-35.2 (C = 2.8). When 25 ℃, water solubility was 4%, solubility is bigger in the hot water. Soluble in ethanol and acetone, slightly soluble in ethyl acetate.

HPLC method for determination the content

(1)Chromatographic conditions: octadecyl silane bonded silica gel as the filling agent; Acetonitrile-0.4% phosphoric acid solution (13:87) as mobile phase; Detection wavelength of 327 nm. Theoretical plate number according to the chromatographic peak of chlorogenic acid is greater than 1000. (2)the preparation of the reference substance solution: precisely weigh the right amount of chlorogenic acid reference substance, placed in brown volumetric flask, adding 50% methanol solution containing 40 μg /mL (saving below 10 ℃). (3)the preparation of sample solution: taking samples of dry powder is about 0.5 g, precision said, with a plug in the conical flask, adding 50 ml 50% methanol , 30 min ultrasonic processing , cooling, weighing, make up the weight loss reduction with 50% methanol, shake well, filtration, abandoned the early filtrate, precision measuring duration of filtrate 5 ml, 25 ml volumetric brown flask , add 50% methanol to the scale, shake well. (4)assimilate precision respectively from each 10 μL reference substance and the sample solution, injection liquid chromatograph, determination,obtained.

Protecting liver, gallbladder

Chlorogenic acid in flos lonicerae has favorable gallbladder function, promoting biliary Secretion of rats. Injection of 200 mg/kg chlorogenic acid to browns MAO honeysuckle total saponins subcutaneous can be significantly against CCl4, paracetamol and the increase of serum GPT caused by galactosamine in mice liver and liver triglyceride levels, and significantly reduce the severity of the liver pathological damage, making dot necrosis number sum and necrosis occur rate liver decreased obviously.
InChI:InChI=1/C16H18O9/c17-9-3-1-8(5-10(9)18)2-4-13(20)25-12-7-16(24,15(22)23)6-11(19)14(12)21/h1-5,11-12,14,17-19,21,24H,6-7H2,(H,22,23)/b4-2+/t11-,12-,14-,16+/m1/s1

327-97-9 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Aldrich (C3878)  Chlorogenicacid  ≥95% (titration) 327-97-9 C3878-5G 3,024.45CNY Detail
Aldrich (C3878)  Chlorogenicacid  ≥95% (titration) 327-97-9 C3878-1G 788.58CNY Detail
Aldrich (C3878)  Chlorogenicacid  ≥95% (titration) 327-97-9 C3878-250MG 320.58CNY Detail
USP (1115545)  Chlorogenicacid  United States Pharmacopeia (USP) Reference Standard 327-97-9 1115545-50MG 4,326.66CNY Detail
Sigma-Aldrich (Y0000569)  Chlorogenicacid  European Pharmacopoeia (EP) Reference Standard 327-97-9 Y0000569 1,880.19CNY Detail
Sigma-Aldrich (00500590)  Chlorogenicacid  primary pharmaceutical reference standard 327-97-9 00500590-25MG 4,319.64CNY Detail
TCI America (C0181)  Chlorogenic Acid Hydrate  >98.0%(HPLC)(T) 327-97-9 5g 2,470.00CNY Detail
TCI America (C0181)  Chlorogenic Acid Hydrate  >98.0%(HPLC)(T) 327-97-9 1g 705.00CNY Detail

327-97-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name chlorogenic acid

1.2 Other means of identification

Product number -
Other names Chlorogenic Acid Hydrate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

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