905-99-7 Usage
Description
Cryptochlorogenic acid, also known as 4-O-caffeoylquinic acid, is a chlorogenic acid isomer found in various plant sources, including the leaves of Hibiscus sabdariffa. It possesses antioxidant and anti-inflammatory properties, making it a valuable compound for various applications.
Uses
Used in Pharmaceutical and Analytical Chemistry:
Cryptochlorogenic acid is used as a reference standard for the determination of its content in plant materials, such as the leaves of Hibiscus sabdariffa, using high-performance liquid chromatography coupled with mass spectrometry (HPLC-MS). This application aids in the accurate quantification and quality control of the compound in herbal products and supplements.
Used in Chromatographic Analysis:
Cryptochlorogenic acid serves as a reference compound in high-performance liquid chromatography-diode array detector (HPLC-DAD) methods, enabling the precise quantification and identification of the compound in complex mixtures. This application is crucial for the development and validation of analytical methods in the pharmaceutical and food industries.
Biochem/physiol Actions
4-O-Caffeoylquinic acid (4-CQA) is a major active antioxidant marker in mulberry leaf extract. It is an inhibitor of ferroptosis hence, it is recognized as a potent anti-diabetic agent. 4-CQA plays an important role in the upregulation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway.
Check Digit Verification of cas no
The CAS Registry Mumber 905-99-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 9,0 and 5 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 905-99:
(5*9)+(4*0)+(3*5)+(2*9)+(1*9)=87
87 % 10 = 7
So 905-99-7 is a valid CAS Registry Number.
InChI:InChI=1/C16H18O9/c17-9-3-1-8(5-10(9)18)2-4-13(21)25-14-11(19)6-16(24,15(22)23)7-12(14)20/h1-5,11-12,14,17-20,24H,6-7H2,(H,22,23)/b4-2+/t11-,12-,14-,16+/m1/s1
905-99-7Relevant articles and documents
Neuroprotective Caffeoylquinic Acid Derivatives from the Flowers of Chrysanthemum morifolium
Yang, Peng-Fei,Feng, Zi-Ming,Yang, Ya-Nan,Jiang, Jian-Shuang,Zhang, Pei-Cheng
, p. 1028 - 1033 (2017/05/05)
Three new caffeoylquinic acid derivatives, chrysanthemorimic acids A-C (1-3), and 11 known compounds (4-14) were isolated and characterized from the flowers of Chrysanthemum morifolium. Their structures were confirmed by spectroscopic data as well as by comparison of the experimental and calculated electronic circular dichroism spectra. Chrysanthemorimic acids A-C possess a rare 8-oxa-bicyclo[3.2.1]oct-3-en-2-one ring that is formed through a [5+2] cycloaddition of caffeoylquinic acid with a d-glucose derivative. Compounds 1-3, 6-8, 12, and 13 displayed significant effects against hydrogen peroxide-induced neurotoxicity in SH-SY5Y cells at 10 μM.
Antioxidant constituents of almond [Prunus dulcis (Mill.) D.A. Webb] hulls
Takeoka, Gary R.,Dao, Lan T.
, p. 496 - 501 (2007/10/03)
Almond hulls (Nonpareil variety) were extracted with methanol and analyzed by reversed phase HPLC with diode array detection. The extract contained 5-O-caffeoylquinic acid (chlorogenic acid), 4-O-caffeoylquinic acid (cryptochlorogenic acid), and 3-O-caffe
Rapid and easy identification of isomers of coumaroyl- and caffeoyl-D-quinic acid by gas chromatography/mass spectrometry
Fuchs, Claus,Spiteller, Gerhard
, p. 602 - 608 (2007/10/03)
The 3-O-, 4-O- and 5-O-isomers of caffeoyl-D-quinic acid and the corresponding ethyl esters were separated by high-performance liquid chromatography and the structures were verified by NMR spectrometry. Trimethylsilylation of the compounds allowed a rapid
