32701-85-2Relevant academic research and scientific papers
PYRAZOLE DERIVATIVES AS P2X7 MODULATORS
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Page/Page column 74, (2009/01/20)
The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof: The pyrazole derivatives of formula (I) or salts thereof modulate P2X7 receptor function and are capable of antagonizing the effects of ATP at the P2
Novel 1,5-diphenylpyrazole nonnucleoside HIV-1 reverse transcriptase inhibitors with enhanced activity versus the delavirdine-resistant P236L mutant: Lead identification and SAR of 3- and 4-substituted derivatives
Genin, Michael J.,Biles, Carolyn,Keiser, Barb J.,Poppe, Susan M.,Swaney, Steven M.,Tarpley, W. Gary,Yagi, Yoshihiko,Romero, Donna L.
, p. 1034 - 1040 (2007/10/03)
Through computationally directed broad screening, a novel 1,5- diphenylpyrazole (DPP) class of HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs) has been discovered. Compound 2 (PNU-32945) was found to have good activity versus wild-type (ICs
Pyrazol-4-acetic acid compounds
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, (2008/06/13)
Pyrazol-4-acetic acid compounds, such as substituted pyrazol-4-acetic acid, its esters, amides, nitriles and their pharamaceutically acceptable salts and method for the preparation of these compounds are disclosed. The novel compounds are useful analgesics, anti-inflammatory, and antipyretics.
