327037-83-2

Upstream product

• 327037-82-1 (S)-2-[(S)-3-(tert-Butoxycarbonyl-methyl-amino)-8-oxo-1-aza-spiro[4.5]deca-6,9-dien-1-yl]-3-(4-methoxy-phenyl)-propionic acid methyl ester 
• 327037-77-4 (S)-2-{(S)-3-(4-Hydroxy-phenyl)-2-[methyl-(4-nitro-benzenesulfonyl)-amino]-propylamino}-3-(4-methoxy-phenyl)-propionic acid methyl ester 
• 327037-78-5 (S)-3-(4-Methoxy-phenyl)-2-{(S)-3-[methyl-(4-nitro-benzenesulfonyl)-amino]-8-oxo-1-aza-spiro[4.5]deca-6,9-dien-1-yl}-propionic acid methyl ester 
• 327037-79-6 {(S)-1-[(S)-1-Formyl-2-(4-methoxy-phenyl)-ethyl]-8-oxo-1-aza-spiro[4.5]dec-3-yl}-methyl-carbamic acid tert-butyl ester 
• 327037-86-5 (S)-3-(4-Methoxy-phenyl)-2-[methyl-(4-nitro-benzenesulfonyl)-amino]-propionic acid methyl ester 
• 327037-85-4 (S)-3-(4-Methoxy-phenyl)-2-(4-nitro-benzenesulfonylamino)-propionic acid methyl ester 
• 327037-88-7 N-[1-hydroxymethyl-2-(4-hydroxy-phenyl)-ethyl]-N-methyl-4-nitro-benzenesulfonamide 
• 327037-81-0 N-[1-formyl-2-(4-hydroxy-phenyl)-ethyl]-N-methyl-4-nitro-benzenesulfonamide 
• 17355-19-0 methyl (S)-2-amino-3-(4-methoxyphenyl)propionate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 327037-80-9 [(1S,3S,6S,7S,8R)-7-Hydroxy-6-(4-methoxy-benzyl)-9-oxo-5-aza-tricyclo[6.3.1.0^1,5]dodec-3-yl]-methyl-carbamic acid tert-butyl ester 

Downstream Products

• 327037-84-3 N-[9-(bisbenzyloxyphosphoryloxy)-7-hydroxy-6-(4-methoxybenzyl)-5-azatricyclo[6.3.1.0^1.5]dodec-3-yl]-N-methylcarbamic acid tert-butyl ester 

Relevant academic research and scientific papers

An enantiospecific synthesis of the potent immunosuppressant FR901483

An azaspiroannulation and an uncommon Mitsunobu reaction are the key steps in a convergent, enantioselective synthesis of the title compound 1. This potent immunosuppressant is derived from a fungus and is distinguished by an unusual monophosphate ester g