327037-84-3

Upstream product

• 1623-08-1 phosphoric acid dibenzyl ester 
• 327037-83-2 [(1S,3S,6S,7S,8S,9R)-7,9-Dihydroxy-6-(4-methoxy-benzyl)-5-aza-tricyclo[6.3.1.0^1,5]dodec-3-yl]-methyl-carbamic acid tert-butyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 844857-14-3 [7,9-bisbenzyloxy-6-(4-methoxybenzyl)-5-azatricyclo[6.3.1.0^1.5]dodec-3-yl]methanol 
• 844857-11-0 7,9-bisbenzyloxy-6-(4-methoxybenzyl)-5-azatricyclo[6.3.1.0^1.5]dodecane-3-carboxylic acid 
• 844857-12-1 [7,9-bisbenzyloxy-6-(4-methoxybenzyl)-5-azatricyclo[6.3.1.0^1.5]dodec-3-yl]carbamic acid methyl ester 
• 844856-98-0 [2-benzyloxy-2-(8-benzyloxy-1,4-dioxaspiro[4.5]dec-7-yl)-1-(4-methoxybenzyl)ethyl]carbamic acid tert-butyl ester 
• 844857-09-6 (1S,3S,6S,7S,8S,9S)-7,9-Bis-benzyloxy-6-(4-methoxy-benzyl)-5-aza-tricyclo[6.3.1.0^1,5]dodecane-3-carbonyl azide 
• 844857-25-6 N-[7,9-bisbenzyloxy-6-(4-methoxybenzyl)-5-azatricyclo[6.3.1.0^1.5]dodec-3-yl]-N-methylcarbamic acid tert-butyl ester 
• 327037-77-4 (S)-2-{(S)-3-(4-Hydroxy-phenyl)-2-[methyl-(4-nitro-benzenesulfonyl)-amino]-propylamino}-3-(4-methoxy-phenyl)-propionic acid methyl ester 
• 327037-78-5 (S)-3-(4-Methoxy-phenyl)-2-{(S)-3-[methyl-(4-nitro-benzenesulfonyl)-amino]-8-oxo-1-aza-spiro[4.5]deca-6,9-dien-1-yl}-propionic acid methyl ester 
• 327037-80-9 [(1S,3S,6S,7S,8R)-7-Hydroxy-6-(4-methoxy-benzyl)-9-oxo-5-aza-tricyclo[6.3.1.0^1,5]dodec-3-yl]-methyl-carbamic acid tert-butyl ester 
• 327037-79-6 {(S)-1-[(S)-1-Formyl-2-(4-methoxy-phenyl)-ethyl]-8-oxo-1-aza-spiro[4.5]dec-3-yl}-methyl-carbamic acid tert-butyl ester 
• 327037-82-1 (S)-2-[(S)-3-(tert-Butoxycarbonyl-methyl-amino)-8-oxo-1-aza-spiro[4.5]deca-6,9-dien-1-yl]-3-(4-methoxy-phenyl)-propionic acid methyl ester 

Relevant academic research and scientific papers

Total synthesis of FR901483

(Chemical Equation Presented) The architecturally sophisticated skeleton of the immurtosuppressfve alkaloid FR901483 was assembled via a process relying on the reaction of an in situ generated !mine with a suitably disposed donor-acceptor cyclopropane. A

A formal total synthesis of (-)-FR901483, using a tandem cationic aza-Cope rearrangement/Mannich cyclization approach

(Chemical Equation Presented) A formal total synthesis of the immunosuppressant FR901483 has been accomplished. The key step in the synthesis utilizes a tandem cationic aza-Cope rearrangement/Mannich cyclization reaction for accessing the unprecedented br

An enantiospecific synthesis of the potent immunosuppressant FR901483

An azaspiroannulation and an uncommon Mitsunobu reaction are the key steps in a convergent, enantioselective synthesis of the title compound 1. This potent immunosuppressant is derived from a fungus and is distinguished by an unusual monophosphate ester g