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VU 0285683
Cas No: 327056-22-4
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BOC Sciences
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VU 0285683
Cas No: 327056-22-4
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ZHEJIANG JIUZHOU CHEM CO.,LTD
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Benzonitrile, 3-fluoro-5-[3-(2-pyridinyl)-1,2,4-oxadiazol-5-yl]-
Cas No: 327056-22-4
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Shanghai united Scientific Co.,Ltd.
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Benzonitrile, 3-fluoro-5-[3-(2-pyridinyl)-1,2,4-oxadiazol-5-yl]-
Cas No: 327056-22-4
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Chemical Co.Ltd
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327056-22-4 Usage

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VU 0285683 is a modulator of metabotropic glutamate receptor 5 (mGluR5) that was developed for the treatment for multiple central nervous system disorders, including anxiety and schizophrenia.

Check Digit Verification of cas no

The CAS Registry Mumber 327056-22-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,2,7,0,5 and 6 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 327056-22:
(8*3)+(7*2)+(6*7)+(5*0)+(4*5)+(3*6)+(2*2)+(1*2)=124
124 % 10 = 4
So 327056-22-4 is a valid CAS Registry Number.

327056-22-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name	3-Fluoro-5-[3-(2-pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile

1.2 Other means of identification

Product number	-
Other names	-

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:327056-22-4 SDS

327056-22-4Upstream product

327056-22-4Downstream Products

327056-22-4Relevant articles and documents

Discovery and characterization of AZD9272 and AZD6538 - Two novel mGluR5 negative allosteric modulators selected for clinical development

Raboisson, Patrick,Breitholtz-Emanuelsson, Anna,Dahlloef, Henrik,Kers, Annika,Minidis, Alexander B. E.,Nordmark, Anna,Stroem, Peter,Terelius, Ylva,Wensbo, David,Edwards, Louise,Isaac, Methvin,Jarvie, Keith,Slassi, Abdelmalik,Wilson, Julie M.,Xin, Tao,Heaton, William L.,Sheehan, Susan M.,McLeod, Donald A.

, p. 6974 - 6979,6 (2020/09/02)

AZD9272 and AZD6538 are two novel mGluR5 negative allosteric modulators selected for further clinical development. An initial high-throughput screening revealed leads with promising profiles, which were further optimized by minor, yet indispensable, structural modifications to bring forth these drug candidates. Advantageously, both compounds may be synthesized in as little as one step. Both are highly potent and selective for the human as well as the rat mGluR5 where they interact at the same binding site than MPEP. They are orally available, allow for long interval administration due to a high metabolic stability and long half-lives in rats and permeate the blood brain barrier to a high extent. AZD9272 has progressed into phase I clinical studies.

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CAS

327056-22-4