32709-74-3Relevant academic research and scientific papers
1-Alkyl-3-amino-5-aryl-1H-[1,2,4]triazoles: Novel synthesis via cyclization of N-Acyl-S-methylisothioureas with alkylhydrazines and their potent corticotropin-Releasing factor-1 (CRF1) receptor antagonist activities
Chen, Chen,Dagnino Jr., Raymond,Huang, Charles Q.,McCarthy, James R.,Grigoriadis, Dimitri E.
, p. 3165 - 3168 (2001)
Cyclizations of alkylhydrazines with N-acyl-S-methylisothioureas, readily synthesized from acyl chlorides, sodium thioisocyanate, dialkylamines then methyl iodide in a one-pot reaction, gave 1-alkyl-3-dialkylamino-5-phenyltriazoles 7 as major products. The regioisomers were assigned through the use of NOE NMR experiments. While bearing a N-bis(cyclopropyl)methyl-N-propylamino group, this series of compounds shows very good binding affinity on the human CRF1 receptor. Among them, 1-methyl-3-[N-bis(cyclopropyl)methyl-N-propylamino]-5-(2,4-dichlorophenyl)- 1H-[1,2,4]triazole 7a had the best binding affinity for the CRF1 receptor (Ki=9 nM).
Synthesis and Characterization of Copper Complexes with the N-(2,6-Diisopropylphenyl)-N′-acylthiourea Ligands
Wang, Dan,Wu, Su-Yun,Li, Hai-Pu,Yang, Ying,Roesky, Herbert W.
supporting information, p. 1406 - 1413 (2017/03/31)
Three N-(2,6-diisopropylphenyl)-N′-acylthiourea ligands [Ar′NHC(S)NHC(O)Ar; Ar′ = 2,6-iPr2C6H3; Ar = p-tBuC6H4 (1, L1), Mes (2, L2), and 1-Naph (3, L3)] were synthesized and compared with the homologous ligand L0 (Ar = Ph) in terms of their resultant complexes with copper halides. The reaction of L1 with CuCl2 led to the formation of mononuclear L12CuCl (4), while treatment of L1 with CuX (X = Cl, Br) resulted in the adamantane cage complexes (L1CuX)4 (X = Cl, 5; Br, 6). These findings are similar to the results shown by its parent ligand L0. The reaction of L1 with CuI yielded the iodide-bridged dimeric complex [L12Cu(μ-I)]2 (7), in contrast to the ligand-bridged dimer supported by L0. L2 readily afforded the mononuclear CuI complexes 8–10 coordinated by two or three ligands. L3 gave monomeric L33CuX (X = Cl, 11; Br, 12) and the iodide-bridged dimeric [L32Cu(μ-I)]2 (13). L3 can bind with CuI halides in a ratio of 1:1 to give complexes L3CuX(PPh3)2 (14–16), when Cu2X2(PPh3)3 (X = Cl, Br) or CuI(PPh3)3 were used as precursors. Treatment of (L1CuCl)4 (5), L22CuBr (8), and L33CuCl (11), respectively, with hot EtOH resulted in the formation of trans-CuLn′2 (17–19) compounds. All compounds were characterized by single-crystal X-ray diffraction studies.
Synthesis and characterization of N,N-Di-substituted acylthiourea copper(II) complexes
Wu, Su-Yun,Zhao, Xiao-Ya,Li, Hai-Pu,Yang, Ying,Roesky, Herbert W.
, p. 883 - 889 (2015/04/27)
A series of six N,N-di-substituted acylthiourea ArC(O)NHC(S)NRR ligands (denoted as HLn) [Ar = 1-Naph: NRR = NPh2, HL1 (1); N(iPr)Ph, HL2 (2). Ar = Mes: NRR = NPh2, HL4 (3); N(iPr)Ph, HLsu
