327165-40-2

Upstream product

• 120417-01-8 <1-(acetyloxy)-2-methyl-2-propenyl>trimethylsilane 
• 40217-17-2 (R)-4-(phenylmethyl)-2-oxazolidinone 
• 372504-89-7 (R)-4-benzyl-2-oxazolidinone lithium salt 
• 749900-07-0 (E)-4-Methyl-5-trimethylsilanyl-pent-4-enoic acid 
• 327165-39-9 tert-butyldimethylsilyl (E)-4-methyl-5-trimethylsilyl-4-pentenoate 

Downstream Products

• 327165-41-3 (4R)-4-benzyl-3-[(2R,3S)-2-(2-methyl-3-trimethylsilyl-E-2-propen-1-yl)-3-hydroxyoctanoyl]-oxazolidin-2-one 
• 327165-43-5 2',6'-di-tert-butyl-4'-methylphenyl (2R,3S,4R,5S)-3-hydroxy-5-(p-methoxybenzyloxy)-2-(methoxymethyleneoxy)-2-methyl-4-(2E-2-methyl-3-trimethylsilylprop-2-enyl)-decanoate 
• 327165-44-6 (2S,3S,4S,5S)-1-acetoxy-3-hydroxy-5-p-methoxybenzyloxy-2-(methoxymethyleneoxy)-2-methyl-4-(2E-2-methyl-3-trimethylsilylprop-2-enyl)decane 
• 327165-60-6 (2S,3S,4R,5S)-3-hydroxy-5-p-methoxybenzyloxy-2-methoxymethyleneoxy-2-methyl-4-(E-2'-methyl-3'-trimethylsilylprop-2'-enyl)decan-1-ol 
• 327165-42-4 (1E,4R,5S)-4-hydroxymethyl-5-p-methoxybenzyloxy-2-methyl-1-trimethylsilyl-1-decene 
• 327165-58-2 (2R,3S)-2-(2-methyl-3-trimethylsilyl-E-prop-2-en-1-yl)-3-(p-methoxybenzyloxy)octanal 
• 327165-57-1 {(E)-3-[(4S,5S)-2-(4-Methoxy-phenyl)-4-pentyl-[1,3]dioxan-5-yl]-2-methyl-propenyl}-trimethyl-silane 

Relevant academic research and scientific papers

Total synthesis of formamicin

The enantioselective total synthesis of the cytotoxic plecomacrolide natural product formamicin (1) is described. Key aspects of this synthesis include the efficient transacetalation reactions of MOM ethers 28 and 38 to form the seven-membered formyl acet

Studies on the Total Synthesis of Formamicin: Synthesis of the C(1)-C(11) Fragment

(Matrix Presented) An efficient and highly concise synthesis of 6, corresponding to the C(1)-C(11) fragment of formamicin (1), has been accomplished by a route utilizing a diastereoselective lactate aldol reaction to set the C(6) tertiary ether and the TE