327183-32-4Relevant articles and documents
The Key Role of the Nonchelating Conformation of the Benzylidene Ligand on the Formation and Initiation of Hoveyda-Grubbs Metathesis Catalysts
Bieszczad, Bartosz,Barbasiewicz, Micha?
, p. 10322 - 10325 (2015/07/07)
Experimental studies of Hoveyda-Grubbs metathesis catalysts reveal important consequences of substitution at the 6-position of the chelating benzylidene ligand. The structural modification varies conformational preferences of the ligand that affects its exchange due to the interaction of the coordinating site with the ruthenium center. As a consequence, when typical S-chelated systems are formed as kinetic trans-Cl2 products, for 6-substituted benzylidenes the preference is altered toward direct formation of thermodynamic cis-Cl2 isomers. Activity data and reactions with tricyclohexylphosphine (PCy3) support also a similar scenario for O-chelated complexes, which display fast trans-Cl2?cis-Cl2 equilibrium observed by NMR EXSY studies. The presented conformational model reveals that catalysts, which cannot adopt the optimal nonchelating conformation of benzylidene ligand, initiate through a high-energy associative mechanism.
Probing of the ligand anatomy: Effects of the chelating alkoxy ligand modifications on the structure and catalytic activity of ruthenium carbene complexes
Barbasiewicz, Michal,Bieniek, Michal,Michrowska, Anna,Szadkowska, Anna,Makal, Anna,Wozniak, Krzysztof,Grela, Karol
, p. 193 - 203 (2008/02/03)
Structural modifications of the Hoveyda-Grubbs ruthenium metathesis complex via electronic and structural withdrawing of the chelating alkoxy ligand were investigated. By decreasing the donor properties of the oxygen atom, an acceleration in catalytic act
4,9-ETHANO-BENZO(F)ISOINDOLE DERIVATIVES AS FARNESYL TRANSFERASE INHIBITORS
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, (2008/06/13)
Novel products of formula (I): STR1 preparation thereof and pharmaceutical compositions containing said products are disclosed. In formula (I), R is a group of formula (CH 2) m X 1 (CH 2) n Z, where X 1 is a simple bond or O or S, n is 0 or 1 and n is 0,