3274-34-8Relevant academic research and scientific papers
Metalation of Hantzsch Esters and Mixed Amide Esters: A General Route to C-2 Functionalized 1,4-Dihydropyridines
Poindexter, Graham S.,Licause, Joseph F.,Dolan, Peter L.,Foley, Michael A.,Combs, Charles M.
, p. 3811 - 3820 (2007/10/02)
1,4-Dihydropyridine (Hantzsch) diesters 3a-e readily undergo metalation at the C-2 methyl (vinylogous ester) position on treatment with alkyllithium bases.The resulting anion intermediates can be treated with electrophilic reagents to afford 1,4-dihydropy
Novel synthese of heterocycles with N-(1-haloalkyl)azinium halides. Part 5. Preparation of N-substituted 1,4-dihydropyridines
Vanden Eynde,Mayence,Maquestiau,Anders
, p. 3291 - 3304 (2007/10/02)
Thirty N-substituted Hantzsch 1,4-dihydropyridines were prepared under mild and neutral conditions from N-substituted enaminocarbonyl derivatives and aldehydes activated under the form of N-(1-chloroalkyl)pyridinium chlorides by means of thionyl chloride
