32750-14-4

Usage

Usage

Building block in organic synthesis and pharmaceutical research

Application

Chiral ligand in asymmetric synthesis and catalysis

Potential properties

Antioxidant and antibacterial

Possible applications

Development of new drugs and materials

Additional uses

Fields of dyes and pigments due to aromatic structure and potential for coloration

Upstream product

• 608-33-3 2,6-dibromophenol 
• 917-54-4 methyllithium 
• 32569-81-6 5,5'-Di-tert-butyl-2,2'-dihydroxy-3,3'-dimethylbiphenyl 

Downstream Products

• 1136-77-2 4,6-dimethyldibenzo[b,d]furan 
• 1207-12-1 4,6-dimethyldibenzothiophene 
• 190841-62-4 Dimethyl-thiocarbamic acid O-(2'-dimethylthiocarbamoyloxy-3,3'-dimethyl-biphenyl-2-yl) ester 

Relevant academic research and scientific papers

Reactions of Alkyl-lithium Compounds with Aryl Halides

Reation of methyl-lithium with tribromophenols and with other aryl polyhalides leads directly to bi- and tri-aryl products. para-Substituents (Y) of 2,6-dibromo-4-Y-phenols promote arylation of substrates by their own lithiation products as Y becomes more electron-withdrawing.An aryne epoxide is not an intermediate in these reactions. 2,4,6-Tribromo-Z-benzenes react to form coupling products when Z can co-ordinate to an introduced ortho-lithium atom or when Z can be directly lithiated.Dimeric aggregation of the organolithium intermediates occurs so as to favor coupling to halogenated substrates.Both polar (ionic) and free-radical pathways are involved.