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1136-77-2

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1136-77-2 Usage

General Description

4,6-dimethyldibenzofuran is a chemical compound with the molecular formula C14H12O. It is a dibenzofuran derivative, a type of aromatic heterocyclic compound. 4,6-dimethyldibenzofuran is a pale yellow solid with a melting point of 101-105°C. It is produced through the methylation of dibenzofuran using suitable reagents. 4,6-dimethyldibenzofuran is used as a precursor for the synthesis of various organic compounds. It has also been studied for its potential applications in organic electronics and as a building block for functional materials. Additionally, 4,6-dimethyldibenzofuran is found in trace amounts in certain plants and foods. It is important to handle this compound with care as it can be harmful if ingested or inhaled.

Check Digit Verification of cas no

The CAS Registry Mumber 1136-77-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,3 and 6 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1136-77:
(6*1)+(5*1)+(4*3)+(3*6)+(2*7)+(1*7)=62
62 % 10 = 2
So 1136-77-2 is a valid CAS Registry Number.
InChI:InChI=1/C14H12O/c1-9-5-3-7-11-12-8-4-6-10(2)14(12)15-13(9)11/h3-8H,1-2H3

1136-77-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 4,6-dimethyldibenzofuran

1.2 Other means of identification

Product number -
Other names 4,6-dimethyl-4-cycloocten-1-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1136-77-2 SDS

1136-77-2Downstream Products

1136-77-2Relevant articles and documents

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Gilman,Young

, p. 1121 (1935)

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Catalyst-Free Synthesis of O-Heteroacenes by Ladderization of Fluorinated Oligophenylenes

Feofanov, Mikhail,Akhmetov, Vladimir,Takayama, Ryo,Amsharov, Konstantin

supporting information, p. 5199 - 5203 (2021/02/21)

A novel catalyst-free approach to benzoannulated oxygen-containing heterocycles from fluorinated oligophenylenes is reported. Unlike existing methods, the presented reaction does not require an oxygen-containing precursor and relies on an external oxygen source, potassium tert-butoxide, which serves as an O2? synthon. The radical nature of the reaction facilitates nucleophilic substitution even in the presence of strong electron-donating groups and enables de-tert-butylation required for the complete annulation. Also demonstrated is the applicability of the method to introduce five-, six-, and seven-membered rings containing oxygen, whereas multiple annulations also open up a short synthetic path to ladder-type O-heteroacenes and oligodibenzofurans.

Pyrazolyl-pyrimidones inhibit the function of human solute carrier protein SLC11A2 (hDMT1) by metal chelation

Embaby, Ahmed,Hediger, Matthias A.,Javor, Sacha,Manatschal, Cristina,Poirier, Marion,Reymond, Jean-Louis,Bühlmann, Sven,Pujol-Giménez, Jonai

supporting information, p. 1023 - 1031 (2020/10/06)

Solute carrier proteins (SLCs) control fluxes of ions and molecules across biological membranes and represent an emerging class of drug targets. SLC11A2 (hDMT1) mediates intestinal iron uptake and its inhibition might be used to treat iron overload diseases such as hereditary hemochromatosis. Here we report a micromolar (IC50 = 1.1 μM) pyrazolyl-pyrimidone inhibitor of radiolabeled iron uptake in hDMT1 overexpressing HEK293 cells acting by a non-competitive mechanism, which however does not affect the electrophysiological properties of the transporter. Isothermal titration calorimetry, competition with calcein, induced precipitation of radioactive iron and cross inhibition of the unrelated iron transporter SLC39A8 (hZIP8) indicate that inhibition is mediated by metal chelation. Mapping the chemical space of thousands of pyrazolo-pyrimidones and similar 2,2′-diazabiaryls in ChEMBL suggests that their reported activities might partly reflect metal chelation. Such metal chelating groups are not listed in pan-assay interference compounds (PAINS) but should be checked when addressing SLCs.

TRANSITION-METAL FREE REDUCTIVE CLEAVAGE OF AROMATIC C-O, C-N, AND C-S BONDS BY ACTIVATED SILANES

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Page/Page column, (2014/04/17)

The present invention describes chemical systems and methods for reducing C—O, C—N, and C—S bonds, said system comprising a mixture of (a) at least one organosilane and (b) at least one strong base, said system being substantially free of a transition-metal compound, and said system optionally comprising at least one molecular hydrogen donor compound, molecular hydrogen, or both.

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