32750-52-0

Basic information

• Product Name: HEXAHYDROPYRIDAZINE-3-CARBOXYLIC ACID
• Synonyms: PIPERAZIC ACID;HEXAHYDROPYRIDAZINE-3-CARBOXYLIC ACID;3-Pyridazinecarboxylic acid, hexahydro-;Hexahydropyridazine-3-carboxylic acid, tech.;Piperazic acid, tech.;Piperidazine-3-carboxylic acid;Piperazine-3-carboxylic acid
• CAS NO: 32750-52-0
• Molecular Formula: C5H10N2O2
• Molecular Weight: 130.15
• Mol File: 32750-52-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 271℃
• Flash Point: 118℃
• Appearance: /
• Density: 1.174
• Vapor Pressure: 0.00188mmHg at 25°C
• Refractive Index: 1.476
• CAS DataBase Reference: HEXAHYDROPYRIDAZINE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: HEXAHYDROPYRIDAZINE-3-CARBOXYLIC ACID(32750-52-0)
• EPA Substance Registry System: HEXAHYDROPYRIDAZINE-3-CARBOXYLIC ACID(32750-52-0)

Safety Data

• Hazardous Substances Data: 32750-52-0(Hazardous Substances Data)

Usage

General Description

Hexahydropyridazine-3-carboxylic acid is a chemical compound with the molecular formula C6H12N2O2. It is a derivative of pyridazine and contains a carboxylic acid functional group. HEXAHYDROPYRIDAZINE-3-CARBOXYLIC ACID has been shown to have potential use in pharmaceutical applications, specifically in the synthesis of bioactive compounds and pharmaceutical intermediates. Hexahydropyridazine-3-carboxylic acid is also used in research and development as a building block for the creation of novel chemical entities. It is important to handle this chemical with care, as it may have various health and environmental hazards associated with its use.

InChI:InChI=1/C5H10N2O2/c8-5(9)4-2-1-3-6-7-4/h4,6-7H,1-3H2,(H,8,9)

Upstream product

• 72064-50-7 (+/-) hexahydropyridazine-3-carboxylic acid hydrochloride 
• 1219380-72-9 N,N'-di-tert-butoxycarbonylpiperazic acid 

Relevant articles and documents

Chloptosin, an apoptosis-inducing dimeric cyclohexapeptide produced by Streptomyces

In the course of screening for apoptosis-inducing agents, chloptosin (1) was isolated from the culture broth of Streptomyces. The dumbbell-type structure of the dimeric cyclohexapeptide consisting of D-valine, (3S)- and (3R)-piperazic acids, O-methyl-L-serine, D-threonine, and (2S,3aR,8aR)-6- chloro-3a-hydroxy-2,3,3a,8a-hexahydropyrrolo[2,3-b]indole-2-carboxylic acid was elucidated by spectroscopic and chemical degradation studies. The amino acid components in each cyclohexapeptide domain were presented in alternating R and S configurations. Chloptosin (1) was found to induce apoptotic activity in apoptosis-resistant human pancreatic adenocarcinoma cell line AsPC-1 and showed a strong antimicrobial activity against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus.

An alternative convenient synthesis of piperidazine-3-carboxylic acid derivatives

The short-step synthesis of the unsubstituted, 5-hydroxy- and 5-chloropiperidazine-3-carboxylic acids using an aza Diels-Alder reaction between the 1,3-diene and azodicarboxylate was described. This synthetic methodology could be used for the preparation