32764-43-5Relevant academic research and scientific papers
Antioxidant activity and Neurite outgrowth-enhancing activity of scorbamic acid and a red pigment derived from ascorbic acid
Ikeda, Nao,Ito, Hideyuki,Iwaoka, Yuji,Ohno, Asako,Tai, Akihiro
, p. 838 - 842 (2020)
L-Ascorbic acid (AA), known as vitamin C, can form browning products by a non-enzymatic process during storage and the browning products cause deterioration of agricultural products. In the browning reaction, a red pigment, 2,2′-nitrilodi-2(2′)-deoxy-L-ascorbic acid ammonium salt (NDA), is generated from AA viaL-scorbamic acid (SCA) as an intermediate. However, the biological activities of SCA and NDA have not yet been clarified. In this study, we assayed the antioxidant activities of SCA and NDA using ABTS radical cation and their neurite outgrowth-enhancing activities in PC12 cells. SCA showed stronger radical-scavenging activity than that of AA, while NDA hardly showed any activity. SCA and NDA enhanced the neurite outgrowth induced by dibutyryl cyclic AMP after their incorporation into cells in the same manner as that of AA. The results indicated that SCA has antioxidant activity and that SCA and NDA have neurite outgrowth-enhancing activity.
On the Yellow Product and Browning of the Reaction of Dehydroascorbic Acid with Amino Acids
Hayashi, Tateki,Hoshii, Yasunari,Namiki, Mitsuo
, p. 1003 - 1010 (2007/10/02)
The ethanolic reaction mixture of dehydroascorbic acid (DHA) and an amino acid contained a significant quantity of a yellow product.During the reaction, this yellow product was found to appear only after the formation of scorbamic acid (SCA) and the red pigment.The reaction of SCA with DHA or with the red pigment (the oxidized form of bis(2-deoxy-2-L-ascorbyl)amine) also produced the same yellow product.Its formation by the DHA-amino acid reaction was supposed to be the direct result of the above SCA-red pigment reaction.The isolated yellow product was examined mainly by spectroscopy, and a possible structure (1) containing one molecular portion each of hydrated DHA, cyclic DHA and AsA resudues, and two nitrogen atoms was proposed.The yellow product is probably a condensation and oxidation product of the reaction between SCA and the red pigment.The formation of the yellow product is probably a key intermediate in this kind of browning reaction.This supposition was as also supported by the highest degree of browning shown by the yellow product among other intermediates.
