32775-08-9

Basic information

• Product Name: [1,2-ethanediylbis(oxy-2,1-ethanediyloxy)]-bis-
• CAS NO: 32775-08-9
• Molecular Weight: 266.248
• Mol File: 32775-08-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: [1,2-ethanediylbis(oxy-2,1-ethanediyloxy)]-bis-(CAS DataBase Reference)
• NIST Chemistry Reference: [1,2-ethanediylbis(oxy-2,1-ethanediyloxy)]-bis-(32775-08-9)
• EPA Substance Registry System: [1,2-ethanediylbis(oxy-2,1-ethanediyloxy)]-bis-(32775-08-9)

Safety Data

• Hazardous Substances Data: 32775-08-9(Hazardous Substances Data)

Usage

General Description

The chemical "[1,2-ethanediylbis(oxy-2,1-ethanediyloxy)]-bis-" is a compound with a complex structure consisting of multiple ethylene glycol units linked together. It is also known as polyethylene glycol diglycidyl ether. [1,2-ethanediylbis(oxy-2,1-ethanediyloxy)]-bis- is used in various industrial applications, including as a cross-linking agent in polymer synthesis, as a surface modifier in nanoparticles and as a component in adhesive and coating formulations. It is also used in the production of resins, plastics, and as a reactive diluent for epoxy resins. Additionally, it is used in the pharmaceutical industry as an excipient in drug formulations and as a component in drug delivery systems. Overall, this compound has a wide range of uses in different fields due to its versatile chemical properties.

Upstream product

• 4792-15-8 Pentaethylene glycol 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 
• 132684-09-4 di-tert-butyl 3,6,9,12-tetraoxatetradecanedioate 

Downstream Products

• 1412423-19-8 C₇₈H₁₀₈N₁₀O₁₆ 
• 84293-33-4 (S)-2-{2-[2-(2-{2-[((S)-1-Carboxy-2-phenyl-ethylcarbamoyl)-methoxy]-ethoxy}-ethoxy)-ethoxy]-acetylamino}-3-phenyl-propionic acid 
• 84293-35-6 (S)-2-{2-[2-(2-{2-[((S)-1-Benzyloxycarbonyl-2-phenyl-ethylcarbamoyl)-methoxy]-ethoxy}-ethoxy)-ethoxy]-acetylamino}-3-phenyl-propionic acid benzyl ester 
• 145058-24-8 N,N-Dibenzyl-2-[2-(2-{2-[(dibenzylcarbamoyl)-methoxy]-ethoxy}-ethoxy)-ethoxy]-acetamide 

Relevant articles and documents

GPER PROTEOLYTIC TARGETING CHIMERAS

A molecule comprising a G-protein coupled estrogen receptor (GPER) ligand coupled to a linker coupled to an E3 ubiquitin ligase ligand and methods of using the molecule are provided. In one embodiment, the GPER ligand is estradiol and the E3 ubiquitin lig

Homo-PROTACs: Bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation

E3 ubiquitin ligases are key enzymes within the ubiquitin proteasome system which catalyze the ubiquitination of proteins, targeting them for proteasomal degradation. E3 ligases are gaining importance as targets to small molecules, both for direct inhibition and to be hijacked to induce the degradation of non-native neo-substrates using bivalent compounds known as PROTACs (for 'proteolysis-targeting chimeras'). We describe Homo-PROTACs as an approach to dimerize an E3 ligase to trigger its suicide-type chemical knockdown inside cells. We provide proof-of-concept of Homo-PROTACs using diverse molecules composed of two instances of a ligand for the von Hippel-Lindau (VHL) E3 ligase. The most active compound, CM11, dimerizes VHL with high avidity in vitro and induces potent, rapid and proteasome-dependent self-degradation of VHL in different cell lines, in a highly isoform-selective fashion and without triggering a hypoxic response. This approach offers a novel chemical probe for selective VHL knockdown, and demonstrates the potential for a new modality of chemical intervention on E3 ligases.

Enhancing the binding properties of a conformationally rigid podand ionophore

Stereospecific functionalization of a conformationally rigid podand yields new ionophores having binding properties comparable to those of the macrocyclic crown ethers.