32780-07-7

Upstream product

• 32780-06-6 (5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran 
• 98-88-4 benzoyl chloride 
• 53716-82-8 1,6-anhydro-3,4-dideoxy-β-D-glycero-hexopyranos-2-ulose 
• 37112-31-5 levoglucosenone 
• 55094-99-0 (–)-(S)-diethyl 2-hydroxyglutarate 
• 56-86-0 L-glutamic acid 
• 21461-84-7 (2S)-tetrahydro-5-oxofuran-2-carboxylic acid 

Downstream Products

• 239125-33-8 (S)-5-benzoyloxymethyl-3-dimethylaminomethylenetetrahydrofuran-2-one 
• 259523-52-9 (S)-5-(benzoyloxymethyl-3-[(E)-(dimethylamino)methylidene])tetrahydrofuran-2-one 
• 28616-91-3 1-(5-O-benzoyl-2,3-dideoxy-β-D-glycero-pentofuranosyl)uracil 
• 132831-84-6 1-(5-O-benzoyl-2,3-dideoxy-β-D-glycero-pentofuranosyl)thymine 
• 132619-89-7 1-(5-O-benzoyl-2,3-dideoxy-α-D-glycero-pentofuranosyl)uracil 
• 117174-28-4 1-bromo-5-O-benzoyl-2,3-dideoxy-D-glycero-pentofuranose 
• 81252-26-8 1-chloro-5-O-benzoyl-2,3-dideoxy-D-glycero-pentofuranose 
• 122621-07-2 1-(5-O-benzoyl-2,3-dideoxy-β-D-glycero-pentofuranosyl)thymine 
• 4097-22-7 2',3'-Dideoxyadenosine 
• 4097-22-7 [(S)-5-(6-Amino-purin-9-yl)-tetrahydro-furan-2-yl]-methanol 
• 117174-29-5 Benzoic acid (S)-5-(6-amino-purin-9-yl)-tetrahydro-furan-2-ylmethyl ester 
• 117174-30-8 Benzoic acid (S)-5-(6-amino-purin-3-yl)-tetrahydro-furan-2-ylmethyl ester 
• 121087-11-4 (S)-2-Benzyloxymethyl-5-bromo-tetrahydro-furan 
• 117248-89-2 (5-O-benzoyl-2,3-dideoxy-α-D-glycero-pentofuranosyl)cytosine 

Relevant academic research and scientific papers

METHOD FOR PRODUCING THIOLANE SKELETON-TYPE GLYCOCONJUGATE, AND THIOLANE SKELETON-TYPE GLYCOCONJUGATE

There is provided a production method of a compound represented by the following formula (II) through a step of reacting a compound represented by the following General Formula (I) with a sulfur compound. In General Formulas (I) and (II), R1 represents a hydrogen atom or an acyl group, R2 represents a hydrogen atom, a fluorine atom, an acyloxy group, an arylmethyloxy group, an allyloxy group, an arylmethyloxycarbonyloxy group, or an allyloxycarbonyloxy group, R3 represents a hydrogen atom or an acyloxy group, R5 represents an alkyl group or an aryl group, and X represents a leaving group. Here, in a case where R2 is a fluorine atom, an acyloxy group, an arylmethyloxy group, an allyloxy group, an arylmethyloxycarbonyloxy group, or an allyloxycarbonyloxy group, R3 is an acyloxy group.

Synthesis of (S)-3-heteroaryl-2-hydroxy-1-propyl benzoates by 'ring switching' methodology

(S)-5-Benzoyloxymethyl-3-[(E)-(dimethylamino)methylidene]tetrahydrofuran-2- one (6), prepared in 5 steps from L-glutamic acid (1), was used as precursor in a one step 'ring switching' synthesis of (S)-2-hydroxy-3-heteroaryl-1-propyl benzoates 13-18, 23, 24. In the reaction of 6 with 2-aminopyridine (21) and 2-amino-4,6-dimethylpyrimidine (22) the corresponding dimethylamine substitution products (25, 26) were obtained.

A METHOD FOR EASY PREPARATION OF OPTICALLY PURE (S)-5-HYDROXY-2-PENTEN-4-OLIDE AND (S)-5-HYDROXYPENTAN-4-OLIDE

A new method for preparation of (S)-5-hydroxy-2-penten-4-olide 1 and (S)-5-hydroxypentan-4-olide 8 starting from levoglucosenone 2 is described.