32785-40-3Relevant academic research and scientific papers
N^N^C platinum (II) complexes based on phenyl-pyridin-2-ylpyrimidine ligands: synthesis, electrochemical and photophysical properties
Achelle, Sylvain,Boixel, Julien,Gauthier, Sébastien,Guen, Fran?oise Robin-le,Hruzd, Mariia,Kahlal, Samia,Saillard, Jean-Yves,le Poul, Nicolas
, (2021/07/13)
A series of luminescent chloro- and alkynyl-platinum (II) complexes containing various tridentate cyclometalated ligands derived from phenyl-pyridin-2-ylpyrimidine and alkynyl ligands has been successfully synthesized and characterized. Their electrochemical, electronic absorption and luminescence properties have been experimentally investigated and supported by (Time-Dependent) Density Functional Theory ((TD)-DFT) calculations. Electrochemical studies show the presence of a ligand-centered reduction originating from the cyclometalating N^N^C ligands, as well as a major ligand-centered oxidation process (N^N^C or alkynyl) with minor contributions of the metal. Most of the complexes exhibits yellow-to-red luminescence at room-temperature in diluted solutions, in frozen matrices and in the solid state. Electron-withdrawing groups on the alkynyl-ligand induce a red shift of the emission band with increased quantum yield in solution. The emission is also sensitive to the position of the pyridyl fragment on the pyrimidine core: complexes with electron-poorer 4-pyridin-2-ylpyrimidine ligands exhibit red-shifted emission and decreased quantum yield compared to their 2-pyridin-4yl analogues. In solid state, chloro-platinum complexes without tBu bulky group exhibit red-shifted excimer emission.
Discovery of 2-(cyclohexylmethylamino)pyrimidines as a new class of reversible valosine containing protein inhibitors
Cervi, Giovanni,Magnaghi, Paola,Asa, Daniela,Avanzi, Nilla,Badari, Alessandra,Borghi, Daniela,Caruso, Michele,Cirla, Alessandra,Cozzi, Liviana,Felder, Eduard,Galvani, Arturo,Gasparri, Fabio,Lomolino, Antonio,Magnuson, Steven,Malgesini, Beatrice,Motto, Ilaria,Pasi, Maurizio,Rizzi, Simona,Salom, Barbara,Sorrentino, Graziella,Troiani, Sonia,Valsasina, Barbara,O'Brien, Thomas,Isacchi, Antonella,Donati, Daniele,D'Alessio, Roberto
, p. 10443 - 10454 (2015/02/19)
Valosine-containing protein (VCP), also known as p97 or cdc48 in yeast, is a highly abundant protein belonging to the AAA ATPase family involved in a number of essential cellular functions, including ubiquitin-proteasome mediated protein degradation, Golgi reassembly, transcription activation, and cell cycle control. Altered expression of VCP has been detected in many cancer types sometimes associated with poor prognosis. Furthermore, VCP mutations are causative of some neurodegenerative disorders. In this paper we report the discovery, synthesis, and structure-activity relationships of substituted 2-aminopyrimidines, representing a new class of reversible VCP inhibitors. This class of compounds, identified in a HTS campaign against recombinant VCP, has been progressively expanded and manipulated to increase biochemical potency and gain cellular activity.
NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS
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Page/Page column 47, (2011/04/14)
The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
Nickel-catalyzed Addition or Coupling Reactions of Grignard Reagents with Halopyrimidines
Elmoghayar, Mohamed R. H.,Groth, Per,Undheim, Kjell
, p. 109 - 114 (2007/10/02)
Phenylmagnesium bromide with NiCl2(dppp) catalysis adds selectively to the unsubstituted position in 2,4-dichlro-5-chloro(fluoro)pyrimidine.X-Ray structure analysis of the hydrolyzed adduct shows an infinite chain by N1 - N3' hydrogen bonding.The hydrolyz
