327989-70-8Relevant academic research and scientific papers
Facile syntheses of conformationally constrained analogues of lysine and homoglutamic acid
Barkallah, Salim,Schneider, Stephen L.,McCafferty, Dewey G.
, p. 4985 - 4987 (2005)
A facile divergent synthesis of the novel amino acid trans-4-aminoethyl-l- proline and trans-4-carboxymethyl-l-proline from commercially available trans-4-hydroxy-l-proline was developed. These conformationally constrained analogues of l-lysine and l-homoglutamic acid are useful proline templated amino acids (PTAAs) with potential applications in protein engineering and de novo protein design.
