327994-60-5Relevant academic research and scientific papers
3,9-Dihydro-2H-[1,2,4]-oxadiazolo[3,2-b]quinazolin-2-ones: First synthesis of the parent heterocycle, 7- and 9-substituted derivatives
Renaut,Durand,Ratel
, p. 2009 - 2012 (2007/10/03)
A first synthesis of 3,9-dihydro-9-aryl-2H-[1,2,4]-oxadiazolo[3,2-b]quinazolin-2-ones is described via the thermal cyclisation of ethyl-(4-aryl-3-oxido-2-quinazolinyl)-carbamates followed by borohydride reduction. A more direct route to 3,9-dihydro-2H-[1,2,4]-oxadiazolo[3,2-b]quinazolin-2-ones, involving the reductive-ring closure of ethyl-(3-oxido-2-quinazolinyl)-carbamate, gives access to the parent unsubstituted heterocycle in good yield. This reaction has been extended to a variety of 7- and 9-substituted 3,9-dihydro-2H-[1,2,4]-oxadiazolo[3,2-b]quinazolin-2-ones.
