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N-(1,1,1-trifluoro-3-phenylpropan-2-yl)acetamide is a complex organic compound with the molecular formula C11H12F3NO. It is a derivative of acetamide, featuring a trifluoromethyl group and a phenylpropan-2-yl moiety. This chemical is characterized by its unique structure, which includes a carbonyl group (C=O) bonded to a nitrogen atom, and a trifluorophenylpropan-2-yl group attached to the nitrogen. The compound is known for its potential applications in pharmaceuticals and agrochemicals, particularly as a building block for the synthesis of more complex molecules. Its specific properties, such as solubility and reactivity, can be influenced by the presence of the trifluoromethyl group, which can enhance lipophilicity and metabolic stability. The compound's synthesis and use often involve advanced organic chemistry techniques, and it is typically handled by professionals in the field due to its potential reactivity and the need for precise control over reaction conditions.

328-61-0

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328-61-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 328-61-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,2 and 8 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 328-61:
(5*3)+(4*2)+(3*8)+(2*6)+(1*1)=60
60 % 10 = 0
So 328-61-0 is a valid CAS Registry Number.

328-61-0Relevant academic research and scientific papers

Chemoenzymatic dynamic kinetic resolution of α-trifluoromethylated amines: Influence of substitutions on the reversed stereoselectivity

Cheng, Guilin,Xia, Bo,Wu, Qi,Lin, Xianfu

, p. 9820 - 9828 (2013/09/02)

Enzymatic resolution of α-trifluoromethylated amines via kinetic resolution (KR), dynamic kinetic resolution (DKR) employing CALB-Pd/Al 2O3, and a one-pot sequential process of KR/DKR/KR was investigated comparatively for the first time. Although CALB-catalyzed KR of α-trifluoromethylated amines with substituents of methyl (1a), isopropyl (1c), phenyl (1d) and benzyl group (1e) can provide good stereoselectivity factors E from 31 to >200 respectively, DKR and sequential process of KR/DKR/KR possess better practical application potential because of the higher conversion (62%-84%) and the similar enantiomeric excesses (90%-99%). The enantiopreference and inversion for the α-trifluoromethylated amines displayed by CALB were observed and explained by docking modes. Namely, for 1,1,1-trifluoro-2-propylamine (1a), the product amide with R-configuration was obtained, and the enantiopreference was converted to S for the amines (1b-1e) with substituents larger than methyl group. The catalysts recycle, and scale-up experiments were demonstrated successfully. All these results indicated the high efficiency and green feature of this enzymatic process, and its application significance.

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