328026-80-8Relevant articles and documents
Discovery of indoline derivatives that inhibit esophageal squamous cell carcinoma growth by Noxa mediated apoptosis
Fu, Dong-Jun,Li, Miaomiao,Zhang, Sai-Yang,Li, Jiang-Feng,Sha, Beibei,Wang, Longhao,Zhang, Yan-Bing,Chen, Ping,Hu, Tao
, (2019/08/27)
A series of novel indoline derivatives were synthesized and evaluated for antiproliferative activity against four selected cancer cell lines (Hela, A549, HepG2 and KYSE30). Among them, compound 20 displayed the potent inhibition activity against esophagea
2-Trifluoroacetylthiophenes, a novel series of potent and selective class II histone deacetylase inhibitors
Jones, Philip,Bottomley, Matthew J.,Carfi, Andrea,Cecchetti, Ottavia,Ferrigno, Federica,Lo Surdo, Paola,Ontoria, Jesus M.,Rowley, Michael,Scarpelli, Rita,Schultz-Fademrecht, Carsten,Steinkuehler, Christian
scheme or table, p. 3456 - 3461 (2009/04/05)
The identification of class II HDAC inhibitors has been hampered by lack of efficient enzyme assays, in the preceding paper two assays have been developed to improve the efficiency of these enzymes: mutating an active site histidine to tyrosine, or by the
