328029-93-2

Upstream product

• 6590-65-4 N-(2-Formyl-phenyl)-4-methyl-benzenesulfonamide 
• 75-52-5 nitromethane 

Downstream Products

• 1448778-17-3 (2'R,3S,4'S)-1-tert-butyl 2'-isopropyl 4'-(nitromethyl)-2-oxo-1'-tosyl-2',4'-dihydro-1'H-spiro[indoline-3,3'-quinoline]-1,2'-dicarboxylate 
• 1448778-18-4 (2'R,3S,4'S)-2'-benzyl 1-tert-butyl 4'-(nitromethyl)-2-oxo-1'-tosyl-2',4'-dihydro-1'H-spiro[indoline-3,3'-quinoline]-1,2'-dicarboxylate 
• 1448778-19-5 (2'R,3S,4'S)-1-tert-butyl 2'-isopropyl 5-fluoro-4'-(nitromethyl)-2-oxo-1'-tosyl-2',4'-dihydro-1'H-spiro[indoline-3,3'-quinoline]-1,2'-dicarboxylate 
• 1448778-20-8 (2'R,3S,4'S)-1-tert-butyl 2'-isopropyl 5-chloro-4'-(nitromethyl)-2-oxo-1'-tosyl-2',4'-dihydro-1'H-spiro[indoline-3,3'-quinoline]-1,2'-dicarboxylate 
• 1448778-21-9 (2'R,3S,4'S)-1-tert-butyl 2'-isopropyl 5-bromo-4'-(nitromethyl)-2-oxo-1'-tosyl-2',4'-dihydro-1'H-spiro[indoline-3,3'-quinoline]-1,2'-dicarboxylate 
• 1448778-22-0 (2'R,3S,4'S)-1-tert-butyl 2'-isopropyl 5-methyl-4'-(nitromethyl)-2-oxo-1'-tosyl-2',4'-dihydro-1'H-spiro[indoline-3,3'-quinoline]-1,2'-dicarboxylate 
• 1448777-99-8 2-((E)-2-nitrovinyl)-N-tosylbenzenamine 

Relevant academic research and scientific papers

Organocatalytic oxa/aza-Michael-Michael cascade strategy for the construction of spiro [chroman/tetrahydroquinoline-3,3′-oxindole] scaffolds

A new useful and effective chiral amine-catalyzed oxa-and aza-Michael-Michael cascade methodology for the construction of enantiomerically enriched indolinones spiro-fused with chromans or tetrahydroquinolines is reported. By employing suitable organocatalysts depending on the different Michael donors (Ar-OH/Ar-NHR), the processes offered excellent stereocontrol (dr >20:1, >99% ee) under mild conditions.