32804-66-3

Basic information

• Product Name: Methyl 3-butynoate
• Synonyms: Methyl 2-Methylbut-3-ynoate;Methyl but-3-ynoate
• CAS NO: 32804-66-3
• Molecular Formula: C₅H₆O₂
• Molecular Weight: 98.1
• Mol File: 32804-66-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 59-61 °C(Press: 50 Torr)
• Appearance: /
• Density: 0.997±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Methyl 3-butynoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-butynoate(32804-66-3)
• EPA Substance Registry System: Methyl 3-butynoate(32804-66-3)

Safety Data

• Hazardous Substances Data: 32804-66-3(Hazardous Substances Data)

Usage

Uses

Methyl But-3-ynoate is used in preparation of phenylalanine derivatives as non-peptide GLP-1 receptor agonists and sensitizers.

Upstream product

• 186581-53-3 diazomethane 
• 2345-51-9 3-butynoic acid 
• 6832-16-2 methyl diazoacetate 
• 74-86-2 acetylene 
• 67-56-1 methanol 
• 85415-22-1 trans-2,3-dibromo-1,4-dichloro-2-butene 
• 85415-23-2 1,1,1-trimethoxy-2,3-butadiene 
• 201230-82-2 carbon monoxide 
• 106-96-7 propargyl bromide 

Downstream Products

• 1427016-29-2 methyl 2-(1-benzyl-1H-1,2,3-triazol-4-yl) acetate 
• 1427016-30-5 C₁₂H₁₂BrN₃O₂ 
• 1427016-31-6 C₁₂H₁₂N₄O₄ 
• 121060-55-7 methyl [2-(4-methoxyphenyl)imidazo[2,1-b][1,3]benzothiazol-3-yl]acetate 
• 121060-54-6 methyl [2-(4-chlorophenyl)imidazo[2,1-b][1,3]benzothiazol-3-yl]acetate 
• 339364-82-8 (4-oxo-cyclohex-1-enyl)-acetic acid methyl ester 
• 1384259-63-5 methyl 2-(5-oxocyclohex-1-enyl)acetate 
• 1042534-65-5 1-(4-(tert-butyl)phenyl)-1H-1,2,3-triazole-4-carboxylic acid 
• 1732-09-8 dimethyl subarate 
• 81834-82-4 (+/-)-15-deoxy-16-methyl-16-hydroxy-3(E)-didehydroprostaglandin E₂ methyl ester 

Relevant articles and documents

Formal metal-free γ-arylation of 1,3-dicarbonyl compounds: Via an isomerisation/1,4-addition/[3,3]-sigmatropic rearrangement sequence

A metal-free redox arylation of alkynes with sulfoxides has been developed to provide unconventional access to diverse γ-arylated 1,3-dicarbonyl compounds in an atom-economical manner. Mechanistic studies suggest that a conjugated allenone intermediate was generated in situ, which solves the problem of reactivity and regioselectivity of unsymmetrical dialkyl-substituted internal alkynes and enables the functionalisation of a broad range of substrates bearing electron-withdrawing functional groups. The resulting arylated 1,3-dicarbonyl compounds are versatile and useful building blocks for further functionalisation. This journal is

CONVENIENT SYNTHESIS OF ALLENYL ESTERS AND AMIDES BY PALLADIUM CATALYZED ALKOXY- AND AMIDO-CARBONYLATION OF ALLENYL AND PROPYNYL HALIDES

Allenyl esters R1R2C=C=C(H)C(O)R (R=OMe) or amides (R=NEt2) are formed with excellent selectivities and in good yields by carbonylation of propynyl and allenyl halides at 1-20 bar CO pressure in benzene, in the presence of MeOH or HNEt2 and 1percent of Pd

METHANOLYSIS OF VICINALLY SUBSTITUTED TETRAHALOGENOBUTENES

The methanolysis of Z,E-1,2,3,4-tetrabromo-1-butene in the presence of strong bases leads predominantly to the formation of the ortho ester 1,1,1-trimethoxy-2,3-butadiene and the ether-acetal 1,1,4-trimethoxy-2-butyne.In the case of E-2,3-dibromo-1,4-dichloro-2-butene it leads predominantly to the ortho ester.During the reaction 10-12 linear unsaturated products containing 1-3 methoxyl groups are formed as side products.