328087-22-5Relevant academic research and scientific papers
Metabolically stabilized benzothiazoles for imaging of amyloid plaques
Henriksen, Gjermund,Hauser, Andrea I.,Westwell, Andrew D.,Yousefi, Behrooz H.,Schwaiger, Markus,Drzezga, Alexander,Wester, Hans-Jürgen
, p. 1087 - 1089 (2007)
Six new N-11C-labeled aminophenylbenzothiazoles substituted with fluorine in different positions have been synthesized and evaluated as amyloid-β binding ligands. Our structure-property relationship studies show that the substitution pattern of
Substituted 2-arylbenzazole compounds and their use as antitumour agents
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Page column 17, (2008/06/13)
Substituted 2-phenylbenzazole compounds of formula (I) wherein X represents S or O and Q represents a direct bond, —CH2— or —CH═Ch—, exhibt selective antiproliferactive activity in respect of mammalian tumour cells. At least in preferred enbodiments the b
Antitumor benzothiazoles. 14. Synthesis and in vitro biological properties of fluorinated 2-(4-aminophenyl)benzothiazoles
Hutchinson,Chua,Browne,Trapani,Bradshaw,Westwell,Stevens
, p. 1446 - 1455 (2007/10/03)
Synthetic routes to a series of mono- and difluorinated 2-(4-amino-3-substituted-phenyl)benzothiazoles have been devised. Whereas mixtures of regioisomeric 5- and 7-fluorobenzothiazoles were formed from the established Jacobsen cyclization of precursor 3-
