328087-20-3Relevant academic research and scientific papers
1-Phenyl-: N -(benzothiazol-2-yl)methanimine derivatives as Middle East respiratory syndrome coronavirus inhibitors
Hu, Min-Qi,Li, Heng,Lin, Ying,Tang, Jie,Tang, Wei,Tong, Xian-Kun,Yang, Fan,Yu, Li-Fang,Zhang, Ying,Zuo, Jian-Ping
, p. 43299 - 43311 (2020/12/25)
Middle East respiratory syndrome coronavirus (MERS-CoV) poses a serious threat to human health, and currently there are no effective or specific therapies available to treat it. Herein a series of 1-phenyl-N-(benzothiazol-2-yl)methanimine derivatives with inhibitory activity against MERS-CoV are described. The compound 4f with a 50% inhibition concentration value of 0.09 μM is a promising inhibitor that warrants further evaluation, towards the development of potential anti-MERS-CoV drugs. This journal is
Metabolically stabilized benzothiazoles for imaging of amyloid plaques
Henriksen, Gjermund,Hauser, Andrea I.,Westwell, Andrew D.,Yousefi, Behrooz H.,Schwaiger, Markus,Drzezga, Alexander,Wester, Hans-Jürgen
, p. 1087 - 1089 (2007/10/03)
Six new N-11C-labeled aminophenylbenzothiazoles substituted with fluorine in different positions have been synthesized and evaluated as amyloid-β binding ligands. Our structure-property relationship studies show that the substitution pattern of
Substituted 2-arylbenzazole compounds and their use as antitumour agents
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Page column 16, (2008/06/13)
Substituted 2-phenylbenzazole compounds of formula (I) wherein X represents S or O and Q represents a direct bond, —CH2— or —CH═Ch—, exhibt selective antiproliferactive activity in respect of mammalian tumour cells. At least in preferred enbodiments the b
Antitumor benzothiazoles. 14. Synthesis and in vitro biological properties of fluorinated 2-(4-aminophenyl)benzothiazoles
Hutchinson,Chua,Browne,Trapani,Bradshaw,Westwell,Stevens
, p. 1446 - 1455 (2007/10/03)
Synthetic routes to a series of mono- and difluorinated 2-(4-amino-3-substituted-phenyl)benzothiazoles have been devised. Whereas mixtures of regioisomeric 5- and 7-fluorobenzothiazoles were formed from the established Jacobsen cyclization of precursor 3-
