328087-60-1Relevant academic research and scientific papers
Synthesis of some new pyrido[2,3-d]pyrimidines and their ribofuranosides as possible antimicrobial agents
Kumar, Neeraj,Singh, Gajendra,Yadav, Ashok K.
, p. 52 - 56 (2007/10/03)
The ribofuranosides, namely, 4-amino-5,7-disubstituted-1-[2′,3′,5′- tri-O-benzoyl-α-D-ribofuranosyl]pyrido-[2,3-d] pyrimidine-2(1H)-thiones, have been synthesized by the condensation of trimethylsilyl derivatives of 5,7-disubstituted pyrido[2,3-d]pyrimidine-2(1H)-thiones with β-D-ribofuranose-1-acetate-2,3,5-tribenzoate in the presence of SnCl4. The heterocyclic bases, namely, 4-amino-5,7-disubstituted pyrido[2,3-d]pyrimidine-2(1H)-thiones, were synthesized by the treatment of 2-amino-3-cyano-4,6-disubstituted pyridines with thiourea. The structures of all the synthesized ribofuranosides and their precursors have been established by elemental analysis, IR, and 1H NMR spectral data. The 13C NMR data of ribofuranosides has also been presented. All the synthesized heterocyclic bases and their ribofuranosides have been screened for their antibacterial and antifungal activities.
Synthesis of some 2-thioxopyrido[2,3-d]pyrimidine ribofuranosides and their antimicrobial activity
Kumar, Neeraj,Singh, Gajendra,Yadav, Ashok K.
, p. 217 - 225 (2007/10/03)
2-Thioxo-3,5,7-trisubstituted-1-[2′,3′.5′-tri-O-benzoyl-β -D-ribofuranosyl]pyrido[2,3-d]pyri midin-4(IH)-ones have been prepared by the condensation of trimethylsilyl derivative of 2-thioxo-3,5,7-trisubstituted pyrido[2,3-d]pyrimidin-4(IH)-ones with β-D-ribofuranose 1-acetate-2,3,5-tribenzoate in 65%-78% yield. The structure of the synthesized ribofuranosides and their precursors have been established by IR. 1H NMR and elemental analysis. These derivatives have been screened for their antimicrobial activity.
