32816-69-6Relevant academic research and scientific papers
Catalyst-free straightforward synthesis of 3-cyano-3-arylamino-2-oxindoles through hydrocyanation with benzoyl cyanide
Chen, Xiao,Li, Zheng
, p. 686 - 693 (2020)
The effective hydrocyanation of 3-(arylimino)indolin-2-ones with benzoyl cyanide under catalyst-free condition at room temperature to synthesize 3-cyano-3-arylamino-2-oxindoles is described. This protocol benefits from low toxicity, inexpensive, and easy-to-handle cyanating agent, no catalysts, no additives, mild conditions, good substrate tolerance, and simple work-up procedure. This reaction successfully offers an alternative to structurally diverse 3,3-disubstituted oxindoles.
Magnetic Fe3O4-BF3: Highly efficient Lewis acid catalyst for the synthesis of α-aminonitriles
Shekouhy, Mohsen,Moaddeli, Ali,Khalafi-Nezhad, Ali
, p. 3805 - 3827 (2016/04/05)
Fe3O4 magnetic nanoparticle-supported BF3 was prepared as a new magnetically separable Lewis acid catalyst and successfully used for the one-pot synthesis of α-aminonitriles. A broad range of substrates including the aromatic and heteroaromatic aldehydes, cyclic ketones (cyclopentanone, cyclohexanone and cycloheptanone), aryl-alkyl ketones, diaryl ketones and tetralones, isatin derivatives and acenaphthenequinone were condensed with amines (aliphatic and aromatic) and trimethylsilyl cyanide. All reactions were completed in short times and products were obtained in good to excellent yields. The catalyst could be recycled and reused several times without any loss of efficiency. Finally, α-aminonitrile containing adenine was successfully synthesized.
