328241-16-3

Upstream product

• 328241-15-2 N⁶-benzoyl-2',3'-O-isopropylidene-5'-O-(triethylsilyl)adenosin-8-yl-(8->7)-8-amino-N⁶-benzoyl-9-[6,7-dideoxy-2,3-O-isopropylidene-5-O-(triethylsilyl)-β-D-allo-hept-6-ynofuranosyl]adenine 
• 994-30-9 triethylsilyl chloride 
• 847205-40-7 N⁶-benzoyl-2',3'-O-isopropylidene-5'-O-(triethylsilyl)adenosin-8-yl-(8->7'-C)-N⁶-benzoyl-9-[6,7-dideoxy-2,3-O-isopropylidene-β-D-allo-hept-6-ynofuranosyl]-8-iodoadenine 

Relevant academic research and scientific papers

Oligonucleosides with a nucleobase-including backbone: Part 12 - Synthesis of mixed ethynylene-linked uridine- and adenosine-derived tetramers

In contradistinction to the corresponding Grignard reagent, bis[(trimethylsilyl)ethynyl]zinc reacted with the 5′-oxoadenosine 3 diastereoselectively to the β-D-allo-hept-6-ynofuranosyladenine 5. Lithiation/iodination of the monomeric propargyl alcohol 5 a

Oligonucleosides with a nucleobase-including backbone: Part 4. A convergent synthesis of ethynediyl-linked adenosine tetramers

Deprotection of the tetramer 24, obtained by coupling the iodinated dimer 18 with the alkyne 23 gave the 8′,5-ethynediyl-linked adenosine-derived tetramer 27 (Scheme 3). As direct iodination of C(5′)-ethynylated adenosine derivatives failed, we prepared 1