328267-64-7

Upstream product

• 1010101-59-3 N-Boc-N-(4-methylphenyl)hydroxylamine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 2835-98-5 2-Hydroxy-4-methylanilin 

Downstream Products

• 866005-27-8 (2-isopropoxy-4-methyl-phenyl)-carbamic acid tert-butyl ester 
• 882424-08-0 N-(4-aminomethyl-2-isopropoxy-phenyl)-methanesulfonamide 
• 866005-35-8 N-(4-azidomethyl-2-isopropoxy-phenyl)-methanesulfonamide 
• 882420-65-7 (4-bromomethyl-2-isopropoxy-phenyl)-carbamic acid tert-butyl ester 
• 866005-31-4 (4-azidomethyl-2-isopropoxy-phenyl)-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Nonsolvent application of ionic liquids: Organo-catalysis by 1-alkyl-3-methylimidazolium cation based room-temperature ionic liquids for chemoselective N-tert-butyloxycarbonylation of amines and the influence of the C-2 hydrogen on catalytic efficiency

1-Alkyl-3-methylimidazolium cation based ionic liquids efficiently catalyze N-tert-butyloxycarbonylation of amines with excellent chemoselectivity. The catalytic role of the ionic liquid is envisaged as "electrophilic activation" of di-tert-butyl dicarbonate (Boc2O) through bifurcated hydrogen bond formation with the C-2 hydrogen of the 1-alkyl-3-methylimidazolium cation and has been supported by a downfield shift of the imidazolium C-2 hydrogen of 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ([bmim][NTf2]) from δ 8.39 to 8.66 in the presence of Boc2O in the 1H NMR and a drastic reduction of the catalytic efficiency with 1-butyl-2,3-dimethylimidazolium ionic liquids that are devoid of the C-2 hydrogen. The differential time required for reaction with aromatic and aliphatic amines has offered means for selective N-t-Boc formation during inter and intramolecular competitions. Preferential N-t-Boc formation with secondary aliphatic amine has been achieved in the presence of primary aliphatic amine. Comparison of the catalytic efficiency for N-t-Boc formation with a common substrate revealed that [bmim][NTf2] is superior to the reported Lewis acid catalysts.

p-diaminobenzene derivative as potassium channel regulator, preparation method and medical applications thereof

The invention relates to a p-diaminobenzene derivative as a potassium channel regulator, a preparation method and medical applications thereof, and specifically discloses a compound represented by a general formula A or a pharmaceutically acceptable salt

2-aminophenols containing electron-withdrawing groups from N -Aryl hydroxylamines

Reaction of substituted N-aryl hydroxylamines with methanesulfonyl chloride, p-toluenesulfonyl chloride, or trifluoromethanesulfonic anhydride under basic conditions leads to the rearranged 2-aminophenols (45-94%). The overall reaction sequence can be per

Analysis of structure-activity relationships for the 'A-region' of N-(4-t-butylbenzyl)-N′-[4-(methylsulfonylamino)benzyl]thiourea analogues as TRPV1 antagonists

The structure-activity relationships for the 'A-region' of N-(4-t-butylbenzyl)-N′-[4-(methylsulfonylamino)benzyl]thiourea analogues have been investigated as TRPV1 receptor antagonists. The 2-halogen analogues showed enhanced antagonism compared to the prototype antagonist.