32829-25-7

Usage

Uses

Used in Organic Synthesis:
1H-[1,2,3]TRIAZOLE-4-CARBALDEHYDE is used as a key building block in organic synthesis for the creation of various chemical compounds. Its unique structure allows for the formation of diverse molecular architectures, making it a valuable component in the synthesis of complex organic molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 1H-[1,2,3]TRIAZOLE-4-CARBALDEHYDE serves as an essential component in the development of new drugs. Its derivatives have been investigated for their potential medicinal applications, including the treatment of various diseases and conditions.
Used in Agrochemical Production:
1H-[1,2,3]TRIAZOLE-4-CARBALDEHYDE is utilized in the production of agrochemicals, which are chemicals used in agriculture to enhance crop yield and protect plants from pests and diseases. Its incorporation into these products contributes to the development of effective and environmentally friendly agrochemicals.
Used in Specialty Chemicals:
1H-[1,2,3]TRIAZOLE-4-CARBALDEHYDE is also employed in the manufacture of specialty chemicals, which are high-value chemicals used in specific applications such as coatings, adhesives, and sealants. The unique properties of 1H-[1,2,3]TRIAZOLE-4-CARBALDEHYDE make it suitable for these specialized uses.
Used in Dyes and Pigments:
1H-[1,2,3]TRIAZOLE-4-CARBALDEHYDE is used in the preparation of dyes and pigments, which are essential for coloring various materials in industries such as textiles, plastics, and paints. Its presence in these products contributes to the development of vibrant and stable colorants.
Used in Fine Chemicals:
In the production of fine chemicals, 1H-[1,2,3]TRIAZOLE-4-CARBALDEHYDE plays a crucial role. Fine chemicals are high-purity chemicals used in various applications, including research, pharmaceuticals, and fragrances. 1H-[1,2,3]TRIAZOLE-4-CARBALDEHYDE's versatility and unique properties make it an indispensable component in the synthesis of these high-quality chemicals.

Upstream product

• 954116-84-8 (indazol-1-yl)-acetic acid ethyl ester 
• 271-44-3 benzimidazole 
• 79-08-3 bromoacetic acid 
• 1137062-64-6 indazol-1-ylacetic acid tert-butyl ester 

Downstream Products

• 13436-48-1 1-methyl-1H-indazole 
• 1111733-79-9 N-(3,4-Dimethyl-phenyl)-2-indazol-1-yl-N-[2-(4-trifluoromethyl-phenyl)-ethyl]-acetamide 

Relevant academic research and scientific papers

Synthesis and structural characterization of 1- and 2-substituted indazoles: Ester and carboxylic acid derivatives

A series of indazoles substituted at the N-1 and N-2 positions with estercontaining side chains -(CH2)nCO2R of different lengths (n = 0-6, 9, 10) are described. Nucleophilic substitution reactions on halo esters (X(CH2)nCO2R) by 1H-indazole in alkaline solution lead to mixtures of N-1 and N-2 isomers, in which the N-1 isomer predominates. Basic hydrolysis of the ester derivatives allowed the synthesis of the corresponding indazole carboxylic acids. All compounds were fully characterised by multinuclear NMR and IR spectroscopies, MS spectrometry and elemental analysis; the NMR spectroscopic data were used for structural assignment of the N-1 and N-2 isomers. The molecular structure of indazol-2-yl-acetic acid (5b) was determined by X-ray diffraction, which shows a supramolecular architecture involving O2-H...N1 intermolecular hydrogen bonds.

COMPOUNDS USEFUL AS CSF1 MODULATORS

This invention relates to novel compounds and to pharmaceutical compositions comprising the novel compounds. More specifically, the invention relates to compounds useful as Colony Stimulating Factor 1 Receptor (cFMS) modulators (e.g. cFMS inhibitors). This invention also relates to processes for preparing the compounds, uses of the compounds in treatment and methods of treatment employing the compounds. Specifically, the invention relates to the use of the compounds for the treatment of cancer and autoimmune diseases.

4-(Benzoimidazol-2-yl)-thiazole Compounds and Related Aza Derivatives

The invention relates to compounds of Formula (I) wherein ring A, X, (R1)n, R2, R3, R4, R4′, R5, n, and p are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds as medicaments, especially as modulators of the CXCR3 receptor.

4-(BENZOIMIDAZOL-2-YL)-THIAZOLE COMPOUNDS AND RELATED AZA DERIVATIVES

The invention relates to compounds of Formula (I) wherein ring A, X, (R1)n, R2, R3, R4, R4', R5, n, and p are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds as medicaments, especially as modulators of the CXCR3 receptor.

Ramoplanin derivatives possessing antibacterial activity

Novel ramoplanin derivatives are disclosed. These ramoplanin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against gram positive bacteria, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.

Triterpene derivatives and endothelin-receptor antagonists containing the same

Triterpene derivatives of the formula (I): STR1 wherein R 1 is hydrogen or metabolic ester residue; and R 2 is hydrogen or --R 3 --R 4 wherein R 3 is --SO 3 --, --CH 2 COO--, --COCOO--, or --COR 5 COO-- (R 5 is lower alkylene or lower alkenylene), and R 4