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13436-48-1

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13436-48-1 Usage

General Description

1-Methylindazole is an organic compound with the chemical formula C8H7N. It is a derivative of indazole, a heterocyclic aromatic compound containing a five-membered ring with two nitrogen atoms. 1-Methylindazole is a colorless to pale yellow liquid with a slightly sweet odor. It is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and dyes. It is also used as a solvent, a corrosion inhibitor, and in the manufacture of rubber and plastic products. 1-Methylindazole is considered to be moderately toxic and may cause irritation to the eyes, skin, and respiratory system. It is important to handle it with proper safety precautions and in a well-ventilated area.

Check Digit Verification of cas no

The CAS Registry Mumber 13436-48-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,4,3 and 6 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 13436-48:
(7*1)+(6*3)+(5*4)+(4*3)+(3*6)+(2*4)+(1*8)=91
91 % 10 = 1
So 13436-48-1 is a valid CAS Registry Number.
InChI:InChI=1/C8H8N2/c1-10-8-5-3-2-4-7(8)6-9-10/h2-6H,1H3

13436-48-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-methylindazole

1.2 Other means of identification

Product number -
Other names 1-Methyl-1H-indazole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:13436-48-1 SDS

13436-48-1Relevant articles and documents

Pd-Catalyzed C-H Annulation of Five-Membered Heteroaryl Halides with Norbornene Derivatives

Padhi, Birakishore,Kang, Geunhee,Kim, Eunmin,Ha, Jeongmin,Kim, Hyun Tae,Lim, Jeewoo,Joo, Jung Min

, p. 1792 - 1798 (2020)

Complementary to Catellani-type reactions and 1:1 coupling of six-membered halo(hetero)arenes and norbornene (NBE) derivatives, Pd-catalyzed 1:2 coupling of five-membered haloheteroarenes with NBEs was achieved to afford rigid nonplanar heterocycles. Pyra

Hetero-dicarbene complexes of palladium(II): Syntheses and catalytic activities

Yuan, Dan,Huynh, Han Vinh

, p. 6033 - 6043 (2014)

A series of Pd(II) dibromido complexes 2-6 bearing cis-chelating hetero-dicarbenes, which contain two different types of NHCs linked by a propylene chain, have been synthesized. In most cases, the N-methylbenzimidazolin-2-ylidene moiety was kept as one NHC donor, while the other one varies with different heterocyclic backbones. As an exception, the hetero-diNHC in complex 8 is derived by combining 1,2,4-triazole and indazole precursors instead. Analogous complexes 9-17, carrying more labile CF3CO2- or CH3CN ligands, were synthesized by reacting the aforementioned bromido complexes with AgO2CCF3 or AgOTf in CH3CN. A systematic catalytic comparison of 9-17 in the direct arylation of pentafluorobenzene with 4-chlorobromobenzene was carried out, and complexes that contain bulkier and less electron-donating ligands were found to be more active. Complex 12, carrying the mesitylimidazolin-2-ylidene unit, proved to be the most efficient, and its activity was also tested in the direct arylation of tetrafluorobenzenes.

Amine-functionalized indazolin-3-ylidene complexes of palladium(II) by postmodification of a single precursor

Bernhammer, Jan C.,Singh, Harvenjit,Huynh, Han Vinh

, p. 4295 - 4301 (2014)

A series of five trans-[PdBr2(amine)(indy)] complexes (amine = diethylamine, dipropylamine, dibutylamine, diisobutylamine, morpholine; indy = indazolin-3-ylidene) with pendant teriary amine functionalities in the side chain of the NHC ligand has been prepared by postcoordinative modification of a single bromoalkyl-functionalized precursor complex. This approach allows for a synthesis of functionalized N-heterocyclic carbene complexes more efficient than the metalation of prefunctionalized azolium salts. All complexes have been fully characterized, and the molecular structures of three complexes are reported. A correlation exists between the 13C NMR shift of C carbene and the pKb values of the coordinated amines. Furthermore, all complexes were found to be active catalysts for the direct arylation of 1-methylpyrrole with good to excellent yields.

Palladium-Catalyzed Oxidative Arylation of 1H-Indazoles with Arenes

Gambouz, Khadija,Abbouchi, Abdelmoula El,Nassiri, Sarah,Suzenet, Franck,Bousmina, Mostapha,Akssira, Mohamed,Guillaumet, Gérald,El Kazzouli, Sa?d

supporting information, p. 7435 - 7439 (2020/11/30)

A simple method for the direct Pd(OAc)2-catalyzed oxidative arylation of inactivated 1H-indazole derivatives with simple arenes is reported. This method exhibits good reaction efficiency and good functional-group tolerance. Using the developed method, 28 arylated products were prepared in yields up to 80 %.

Alkylation method for nitrogen-hydrogen containing compounds and application thereof

-

Paragraph 0059; 0060, (2018/10/04)

The invention discloses an alkylation method for nitrogen-hydrogen containing compounds and an application thereof, belonging to the technical field of synthesis of organic compounds. The invention provides a series of methods for a nitrogen alkylation reaction of N-H containing heterocyclic compounds (II) with N,N-dimethylformamide dialkyl acetal as an alkyl source under the condition of no participation of metals, and a product with a hydrogen atom on a nitrogen atom substituted by R1 is obtained. The method provided by the invention has the advantages of highly-efficient reaction, high yield, simple treatment after the reaction, simple and convenient operation, mild reaction conditions, no participation of the metals, high tolerance of functional groups of a reaction substrate, wide range and easy preparation of the substrate, high reaction efficiency after amplification of the reaction, and applicability to large-scale industrial production.

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