328404-70-2

Basic information

• Product Name: (1R,7R,8R)-7-(tert-butyldiphenylsilyloxy)-1-(tert-butyldimethylsilyloxymethyl)pyrrolizidine
• Synonyms: (1R,7R,8R)-7-(tert-butyldiphenylsilyloxy)-1-(tert-butyldimethylsilyloxymethyl)pyrrolizidine
• CAS NO: 328404-70-2
• Molecular Weight: 634.021
• Mol File: 328404-70-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (1R,7R,8R)-7-(tert-butyldiphenylsilyloxy)-1-(tert-butyldimethylsilyloxymethyl)pyrrolizidine(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,7R,8R)-7-(tert-butyldiphenylsilyloxy)-1-(tert-butyldimethylsilyloxymethyl)pyrrolizidine(328404-70-2)
• EPA Substance Registry System: (1R,7R,8R)-7-(tert-butyldiphenylsilyloxy)-1-(tert-butyldimethylsilyloxymethyl)pyrrolizidine(328404-70-2)

Safety Data

• Hazardous Substances Data: 328404-70-2(Hazardous Substances Data)

Upstream product

• 389874-45-7 3-(tert-butyl-diphenyl-silanyloxy)-2-[1-(tert-butyl-diphenyl-silanyloxymethyl)-but-3-enyl]-pyrrolidine-1-carboxylic acid benzyl ester 
• 328404-68-8 3-(tert-butyl-diphenyl-silanyloxy)-2-[1-(tert-butyl-diphenyl-silanyloxymethyl)-3-hydroxy-propyl]-pyrrolidine-1-carboxylic acid benzyl ester 
• 328404-66-6 (3R)-1-(benzyloxycarbonyl)-3-hydroxy-2-[2-(4-pentenyl-1-ol)]pyrrolidine 
• 328404-64-4 (1R,4R,5R)-6-(benzyloxycarbonyl)-4-(3-propenyl)-6-aza-2-oxa-bicyclo[3.3.0]-3-octanone 
• 328404-56-4 (R)-3-[(1-bezyloxy-carbonyl)-pyrrolidinyl]-α-diazoacetate 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 95456-65-8 (1R,5R)-(-)-6-aza-6-benzyloxycarbonyl-2-oxabicyclo[3.3.0]octan-3-one 
• 328404-69-9 3-(tert-butyl-diphenyl-silanyloxy)-2-[1-(tert-butyl-diphenyl-silanyloxymethyl)-3-methanesulfonyloxy-propyl]-pyrrolidine-1-carboxylic acid benzyl ester 

Downstream Products

• 21850-67-9 (-)-turneforcidine 

Relevant articles and documents

A dirhodium(II)-carbenoid route to (-)- and (+)-Geissman-Waiss lactone: Synthesis of (1R,7R,8R)-(-)-turneforcidine

(-)- and (+)-Geissman-Waiss lactone, 4b, was efficiently prepared via the intramolecular C-H insertion reaction of the chiral nonracemic diazoacetates (-)-5a and (+)-5b catalyzed by dirhodium(II) tetrakis[methyl (5R and 5S)-3-phenylpropanoyl-2-imidazolidinone-5-carboxylate]. The cyclization was found to proceed with excellent regioselectivity and cis-diastereoselectivity. The bicyclic lactone (-)-4b was successfully used in the synthesis of the necine base, (-)-turneforcidine 2.