328537-73-1Relevant academic research and scientific papers
A model study for the total synthesis of (±)-scopadulin: Stereoselective construction of the A/B ring system with desired functionalities
Abdur Rahman,Ohno, Hiroaki,Yoshino, Hitoshi,Satoh, Norifumi,Tsukaguchi, Mahoto,Murakami, Kazuo,Iwata, Chuzo,Maezaki, Naoyoshi,Tanaka, Tetsuaki
, p. 127 - 134 (2001)
A model study toward the total synthesis of (±)-scopadulin is described. Stereocontrolled synthesis of the A/B ring system with desired functionalities was achieved by stereoselective cyanation of a bicyclic enone with Et2AlCN, diastereoselective construction of a quaternary carbon at C-4 with LDA-BOMCl, and conversion of the cyano group into a methyl group.
A selective C-H insertion/olefination protocol for the synthesis of α-methylene-γ-butyrolactone natural products
Lloyd, Matthew G.,D'Acunto, Mariantonietta,Taylor, Richard J. K.,Unsworth, William P.
supporting information, p. 1641 - 1645 (2016/02/09)
A regio- and stereoselective one-pot C-H insertion/olefination protocol has been developed for the late stage installation of α-methylene-γ-butyrolactones into conformationally restricted cyclohexanol-derivatives. The method has been successfully applied in the total synthesis of eudesmanolide natural product frameworks, including α-cyclocostunolide.
